The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort.
The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort.
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DOI：
10.1093/ije/dyw307
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发表时间：
2017-04-01
影响因子：
7.7
通讯作者：
Relton CL
中科院分区：
文献类型：
--
作者：
Simpkin AJ;Howe LD;Tilling K;Gaunt TR;Lyttleton O;McArdle WL;Ring SM;Horvath S;Smith GD;Relton CL
背景资料：最近开发了使用个体DNA甲基化水平来估计其年龄的统计模型（称为表观遗传时钟），表观遗传和实足年龄之间的相关性为96%。我们假设，估计年龄和实际年龄之间的差异[年龄加速（AA）]可以作为衡量早期生活中的发育年龄。 研究方法：我们在三个时间点（出生，7岁和17岁）在1018名儿童从雅芳纵向研究的父母和儿童（ALSPAC）的DNA甲基化措施。使用在线计算器，我们估计了每个孩子在每个时间点的表观遗传年龄，从而AA。然后，我们研究AA是否与身高、体重、体重指数（BMI）、骨密度、骨量、脂肪量、瘦体重和坦纳分期的重复测量值前瞻性相关。 结果如下：出生时AA阳性与从出生到青春期（即0-17岁）的较高平均脂肪量[每年AA 1321 g，95%置信区间（CI）386，2256 g]相关，7岁时AA与较高平均身高相关（每年AA 0.23 cm，95% CI 0.04，0.41 cm）。还发现了AA（出生时和儿童期）在发育过程中变化的作用的证据，较高的AA与体重、BMI和坦纳分期的变化呈正相关，但与身高和脂肪量的变化呈负相关。 结论：我们发现证据表明，在一个人的表观遗传年龄加速之前，与儿童和青少年时期的发育特征有关。这表明了在未来的研究中使用AA作为发展指标的潜力。
Background: Statistical models that use an individual’s DNA methylation levels to estimate their age (known as epigenetic clocks) have recently been developed, with 96% correlation found between epigenetic and chronological age. We postulate that differences between estimated and actual age [age acceleration (AA)] can be used as a measure of developmental age in early life. Methods: We obtained DNA methylation measures at three time points (birth, age 7 years and age 17 years) in 1018 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Using an online calculator, we estimated epigenetic age, and thus AA, for each child at each time point. We then investigated whether AA was prospectively associated with repeated measures of height, weight, body mass index (BMI), bone mineral density, bone mass, fat mass, lean mass and Tanner stage. Results: Positive AA at birth was associated with higher average fat mass [1321 g per year of AA, 95% confidence interval (CI) 386, 2256 g] from birth to adolescence (i.e. from age 0–17 years) and AA at age 7 was associated with higher average height (0.23 cm per year of AA, 95% CI 0.04, 0.41 cm). Conflicting evidence for the role of AA (at birth and in childhood) on changes during development was also found, with higher AA being positively associated with changes in weight, BMI and Tanner stage, but negatively with changes in height and fat mass. Conclusions: We found evidence that being ahead of one’s epigenetic age acceleration is related to developmental characteristics during childhood and adolescence. This demonstrates the potential for using AA as a measure of development in future research.
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影响因子：
7.7
作者：
Cole TJ;Donaldson MD;Ben-Shlomo Y
通讯作者：
Ben-Shlomo Y
影响因子：
3.7
作者：
Bocklandt S;Lin W;Sehl ME;Sánchez FJ;Sinsheimer JS;Horvath S;Vilain E
通讯作者：
Vilain E
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
3.8
作者：
Dedeurwaerder, Sarah;Defrance, Matthieu;Fuks, Francois
通讯作者：
Fuks, Francois
影响因子：
2.3
作者：
Howe LD;Tilling K;Matijasevich A;Petherick ES;Santos AC;Fairley L;Wright J;Santos IS;Barros AJ;Martin RM;Kramer MS;Bogdanovich N;Matush L;Barros H;Lawlor DA
通讯作者：
Lawlor DA