Biofilm formation by hyperpiliated mutants of Pseudomonas aeruginosa
Biofilm formation by hyperpiliated mutants of Pseudomonas aeruginosa
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DOI：
10.1128/jb.185.7.2374-2378.2003
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发表时间：
2003-04-01
影响因子：
3.2
通讯作者：
Burrows, LL
中科院分区：
文献类型：
--
作者：
Chiang, P;Burrows, LL
在静态生长条件下，hyperpiliated，nontripping pilT和皮鲁突变体的铜绿假单胞菌形成致密的生物膜，表明粘附，而不是抽搐的运动，是必要的生物膜的启动。在流动条件下，pilT突变体形成的蘑菇样结构大于野生型，但皮鲁突变体是有缺陷的生物膜形成。因此，抽搐运动影响生物膜结构的发展，可能是通过调制脱离。
Under static growth conditions, hyperpiliated, nontwitching pilT and pilU mutants of Pseudomonas aeruginosa formed dense biofilms, showing that adhesion, not twitching motility, is necessary for biofilm initiation. Under flow conditions, the pilT mutant formed mushroom-like structures larger than those of the wild type but the pilU mutant was defective in biofilm formation. Therefore, twitching motility affects the development of biofilm structure, possibly through modulation of detachment.