Making polymeric micro- and nanoparticles of complex shapes
Making polymeric micro- and nanoparticles of complex shapes
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DOI：
10.1073/pnas.0705326104
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发表时间：
2007-07-17
影响因子：
11.1
通讯作者：
Mitragotri, Samir
中科院分区：
文献类型：
--
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
聚合物微米和纳米颗粒在药物输送、医学成像和先进材料等各种应用中以及在微流体和纳米技术等领域的基础研究中发挥着核心作用。聚合物颗粒在这些领域中的功能行为受到其形状的强烈影响。然而，精确形状的聚合物粒子的可用性一直是理解和利用形状在粒子功能中的作用的主要瓶颈。在这里，我们报告一种直接满足这一需求的方法。我们的方法使用常规的实验室化学品和设备来制造具有不同形状和特征的颗粒，大小从60 nm到30微米不等。这种方法可以独立控制重要的颗粒属性，如大小和形状，这对开发非球形颗粒作为各种领域的工具和产品至关重要。
Polymeric micro- and nanoparticles play a central role in varied applications such as drug delivery, medical imaging, and advanced materials, as well as in fundamental studies in fields such as microfluidics and nanotechnology. Functional behavior of polymeric particles in these fields is strongly influenced by their shape. However, the availability of precisely shaped polymeric particles has been a major bottleneck in understanding and capitalizing on the role of shape in particle function. Here we report a method that directly addresses this need. Our method uses routine laboratory chemicals and equipment to make particles with >20 distinct shapes and characteristic features ranging in size from 60 nm to 30 mu m. This method offers independent control over important particle properties such as size and shape, which is crucial to the development of nonspherical particles both as tools and products for a variety of fields.