Risk assessment of coumarin using the bench mark dose (BMD) approach: Children in Norway which regularly eat oatmeal porridge with cinnamon may exceed the TDI for coumarin with several folds
Risk assessment of coumarin using the bench mark dose (BMD) approach: Children in Norway which regularly eat oatmeal porridge with cinnamon may exceed the TDI for coumarin with several folds
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DOI：
10.1016/j.fct.2011.12.005
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发表时间：
2012-03-01
影响因子：
4.3
通讯作者：
Husoy, T.
中科院分区：
文献类型：
--
作者：
Fotland, T. O.;Paulsen, J. E.;Husoy, T.
香豆素是肉桂和许多其他植物中天然存在的调味物质。已知香豆素可导致几种物种的肝毒性，并且认为其在啮齿动物中是非遗传毒性致癌物。通过使用基准剂量方法，我们重新评估了香豆素毒性，并确定了香豆素的新TDI为0.07 mg/kg bw/天。口服香豆素的摄入量与食用含有肉桂的食物和食品补充剂有关。肉桂是挪威广泛使用的香料，可用作燕麦粥的配料。根据对挪威食品中香豆素的分析，对儿童和成人的摄入量进行了计算，并对挪威人口中的香豆素进行了风险评估。香豆素的摄入量估计显示，幼儿每周食用几次洒有肉桂的燕麦粥，香豆素摄入量可能为1.63 mg/kg bw/天，可能超过TDI数倍。成年人饮用肉桂茶和食用肉桂补充剂也可能超过TDI。在某些摄入情况下，香豆素摄入量可能超过TDI 7至20倍。如此大的TDI日摄入量，即使是在1-2周的有限时间内，也会引起对健康不利影响的担忧。(C)2011爱思唯尔有限公司保留所有权利。
Coumarin is a naturally occurring flavouring substance in cinnamon and many other plants. It is known that coumarin can cause liver toxicity in several species, and it is considered a non-genotoxic carcinogen in rodents. By using the bench mark dose approach we re-assessed coumarin toxicity and established a new TDI for coumarin of 0.07 mg/kg bw/day. Oral intake of coumarin is related to consumption of cinnamon-containing foods and food supplements. Cinnamon is a widely used spice in Norway, and can be used as topping on oatmeal porridge. Based on analyses of coumarin in Norwegian foods, intake calculations for children and adults were conducted, and a risk assessment of coumarin in the Norwegian population was performed. Intake estimates of coumarin show that small children eating oatmeal porridge several times a week sprinkled with cinnamon could have a coumarin intake of 1.63 mg/kg bw/day and may exceeding the TDI with several folds. Adults drinking cinnamon-based tea and consuming cinnamon supplements also can exceed TDI. The coumarin intake could exceed the TDI by 7- to 20-fold in some intake scenarios. Such large daily exceedances of TDI, even for a limited time period of 1-2 weeks, cause concern of adverse health effects. (C) 2011 Elsevier Ltd. All rights reserved.