Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking
Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking
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DOI：
10.1089/ars.2006.8.1891
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发表时间：
2006-09-01
影响因子：
6.6
通讯作者：
Yodoi, Junji
中科院分区：
文献类型：
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作者：
Sato, Atsuyasu;Hara, Tomijiro;Yodoi, Junji
硫氧还蛋白-1（TRX）是一种小分子氧化还原活性蛋白，具有抗氧化作用和氧化还原调节功能。吸烟是多种疾病发病机制中的主要致病因素，并引起全身免疫和炎症反应。本报告表明，TRX减弱吸烟诱导的全身炎症反应。与对照组C57 BL/6小鼠相比，吸烟可抑制TRX过表达转基因小鼠（TRX-tg）脾脏中肿瘤坏死因子α（TNF-α）和巨噬细胞移动抑制因子（MIF）mRNA的表达。此外，蛋白质羰基化，细胞蛋白质氧化的标志物，在对照组小鼠的心脏和肝脏组织中，吸烟比TRX-tg小鼠更增强。这些结果表明，TRX可能抑制吸烟引起的全身炎症反应。
Thioredoxin-1 (TRX) is a small redox-active protein with antioxidative effects and redox-regulating functions. Cigarette smoking is a major etiological factor in the pathogenesis of a variety of diseases and recruits systemic immune and inflammatory responses. This report demonstrates that TRX attenuates the systemic inflammatory responses induced by cigarette smoking. The mRNA expressions of tumor necrosis factor alpha (TNF-alpha) and macrophage migration inhibitory factor (MIF) were suppressed in the spleen of TRX over-expressing transgenic mice (TRX-tg) exposed to cigarette smoking, compared with control C57BL/6 mice. In addition, protein carbonylation, a marker of cellular protein oxidation, was enhanced by cigarette smoking in the tissues of heart and liver in control mice more than in TRX-tg mice. These findings suggest that TRX may suppress the systemic inflammatory responses against cigarette smoking.