Expanding the primate body schema in sensorimotor cortex by virtual touches of an avatar.
Expanding the primate body schema in sensorimotor cortex by virtual touches of an avatar.
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通过虚拟人物的虚拟触摸来扩展感觉运动皮层中的灵长类动物身体模式。
DOI：
10.1073/pnas.1308459110
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发表时间：
2013
影响因子：
11.1
通讯作者：
Nicolelis,MiguelAL
中科院分区：
文献类型：
--
作者：
Shokur,Solaiman;O'Doherty,JosephE;Winans,JesseA;Bleuler,Hannes;Lebedev,MikhailA;Nicolelis,MiguelAL
大脑对身体的表征，称为身体图式，对可塑性很敏感。例如，体验橡皮手错觉的受试者，当他们看到人体模型的手被触摸时，他们会产生一种归属感，同时触觉刺激也会施加到他们自己的手上。在这里，通过同时记录来自初级躯体感觉(即，S1)和运动(即，M1)皮质神经元集合的同时记录，当两只猴子观察到化身手臂被虚拟球触摸时，研究了这种实施例的皮质基础。在虚拟触摸与猴子手臂的物理刷子同步发生一段时间后，S1和M1中的神经元开始对单独应用的虚拟触摸做出反应。对虚拟触摸的反应比对物理触摸的反应晚50到70ms，这与连接视觉皮质与S1和M1的多突触通路的参与是一致的。我们认为，S1和M1有助于橡皮手错觉，通过利用这些区域的可塑性，患者可以吸收神经假肢作为其身体模式的一部分。
The brain representation of the body, called the body schema, is susceptible to plasticity. For instance, subjects experiencing a rubber hand illusion develop a sense of ownership of a mannequin hand when they view it being touched while tactile stimuli are simultaneously applied to their own hand. Here, the cortical basis of such an embodiment was investigated through concurrent recordings from primary somatosensory (i.e., S1) and motor (i.e., M1) cortical neuronal ensembles while two monkeys observed an avatar arm being touched by a virtual ball. Following a period when virtual touches occurred synchronously with physical brushes of the monkeys' arms, neurons in S1 and M1 started to respond to virtual touches applied alone. Responses to virtual touch occurred 50 to 70 ms later than to physical touch, consistent with the involvement of polysynaptic pathways linking the visual cortex to S1 and M1. We propose that S1 and M1 contribute to the rubber hand illusion and that, by taking advantage of plasticity in these areas, patients may assimilate neuroprosthetic limbs as parts of their body schema.