Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems
Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems
复制标题
DOI：
10.1039/c0cc05222a
复制
发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Marek, Ilan
中科院分区：
文献类型：
--
作者：
Das, Jaya Prakash;Marek, Ilan
在无环体系中产生全碳季胺立体中心的大多数方法是在过去十年中发展起来的，显示了这一研究领域的当代兴趣。最初的策略，其中手性实体连接到碳骨架，对映选择性催化，最后的策略，其中几个碳-碳键在一锅操作中创建，反映了在设计和执行合成序列的不断努力和创造力。这篇专题文章总结了这些反应序列，并分为取代和加成反应、烷基化反应、羟醛缩合反应、曼尼希反应和重排反应。可以安全地预测，这一化学领域将在未来几十年内继续呈指数级增长，并且这些手性实体的广泛可用性将为进一步丰富主流合成方法提供极好的机会。
Most of the methods for the creation of all-carbon quaternary stereogenic centers in acyclic systems were developed in the last decade showing the contemporary interest of this field of research. Initial strategies, where chiral entities were linked to carbon skeleton, to enantioselective catalysis and finally to strategies where several carbon-carbon bonds were created in a single-pot operation, reflect the constant strive and creativity in the design and execution of synthetic sequences. This feature article summarizes these sequences and is divided into sections on substitution and additions reactions, alkylation, aldol, Mannich and rearrangements reactions. It is safe to predict that this field of chemistry will continue to grow exponentially in the coming decades and the ready availability of a wide range of these chiral entities will provide an excellent opportunity to further enrich mainstream synthetic methodologies.