Genome-wide association study reveals novel loci associated with fat-deposition and meat-quality traits in Pekin ducks
Genome-wide association study reveals novel loci associated with fat-deposition and meat-quality traits in Pekin ducks
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DOI：
10.1111/age.12995
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发表时间：
2020-08-26
期刊：
影响因子：
2.4
通讯作者：
Hou, Z-C
中科院分区：
文献类型：
--
作者：
Deng, M-T;Zhang, F.;Hou, Z-C
肉质性状在肉禽生产中起着至关重要的作用。为了确定北京鸭肉品质的遗传机制，本研究对影响北京鸭肉品质的数量性状位点进行了大规模GWAS鉴定。我们测量了542只北京鸭的10个性状，并采用基因分型测序方法对每只鸭进行了基因分型。对10个肉质相关性状的遗传参数（遗传力、遗传相关）进行了评价。基于大型基因型-表型数据集，我们对所有这些性状进行了GWASs。通过位点分析，共鉴定出13条染色体上的33个显著QTL （P < 3.03 × 10(-5)）。发现了一些新发现的脂肪沉积和肉质性状的候选基因，包括体重和内脏重量的pag1，腹部脂肪重量和比例的intuandnup35，皮肤脂肪重量和比例的nup3和arhgdib，乳房肌肉韧性和乳房柔软的golga5，乳房肌肉厚度的ctdsplandpkp1。本研究首次对鸭肉品质进行了系统的研究。
Meat-quality traits play an essential role in meat poultry production. To determine the genetic mechanisms of meat quality in Pekin ducks, we performed a large-scale GWAS to identify quantitative trait loci affecting meat quality in Pekin ducks. We measured 10 traits in 542 Pekin ducks and genotyped each duck using genotyping-by-sequencing. The genetic parameters (genomic heritability, genetic correlation) for 10 meat-quality related traits were evaluated. Based on the large genotype-phenotype dataset, we performed GWASs for all of these traits. A total of 33 significant QTL (P < 3.03 x 10(-5)) across 13 chromosomes were identified by loci-based analysis. Some newly identified candidate genes were discovered for fat-deposition and meat-quality traits, includingPAG1for body weight and eviscerated weight,INTUandNUP35for abdominal fat weight and ratio,NUP3andARHGDIBfor skin fat weight and ratio,GOLGA5for breast muscle toughness and breast tenderness, andCTDSPLandPKP1for breast muscle thickness. The current study is the first systematic report regarding duck meat quality.