Nanocarriers for vascular delivery of antioxidants.
Nanocarriers for vascular delivery of antioxidants.
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DOI：
10.2217/nnm.11.92
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Muzykantov V
中科院分区：
文献类型：
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作者：
Hood E;Simone E;Wattamwar P;Dziubla T;Muzykantov V
抗氧化酶（AOE）过氧化氢酶和超氧化物歧化酶（SOD）解毒有害的活性氧，但AOE的治疗效用是阻碍了不充分的交付。通过聚乙二醇（PEG）修饰AOE并包封在PEG包被的脂质体中增加了AOE的生物利用度，并增强了动物模型中的保护作用。与AOE形成的基于Pluronic的胶束显示出更有效的保护作用。此外，基于PEG-共聚物的聚合物纳米载体（PNC）保护包封的AOE免受蛋白水解并改善向靶细胞（例如血管腔内衬的内皮）的递送。与AOE或AOE载体缀合的内皮决定簇的抗体提供靶向和细胞内递送。靶向脂质体、蛋白质缀合物和磁性纳米颗粒将AOE递送到心血管、肺和神经系统中的血管氧化应激位点。用于AOE递送的纳米设备的进一步进展将为这种方法在临床领域的转化提供基础。
Antioxidant enzymes (AOEs) catalase and superoxide dismutase (SOD) detoxify harmful reactive oxygen species, but the therapeutic utility of AOEs is hindered by inadequate delivery. AOE modification by polyethylene glycol (PEG) and encapsulation in PEG-coated liposomes increases the AOE bioavailability and enhances protective effects in animal models. Pluronic-based micelles formed with AOEs show even more potent protective effects. Furthermore, polymeric nanocarriers (PNCs) based on PEG-copolymers protect encapsulated AOEs from proteolysis and improve delivery to the target cells, such as the endothelium lining the vascular lumen. Antibodies to endothelial determinants conjugated to AOEs or AOE carriers provide targeting and intracellular delivery. Targeted liposomes, protein conjugates and magnetic nanoparticles deliver AOEs to sites of vascular oxidative stress in the cardiovascular, pulmonary and nervous systems. Further advances in nanodevices for AOE delivery will provide a basis for the translation of this approach in the clinical domain.