The effects of sevoflurane on cerebral blood flow autoregulation in rats
The effects of sevoflurane on cerebral blood flow autoregulation in rats
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DOI：
10.1097/00000539-199810000-00020
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发表时间：
1998-10-01
影响因子：
5.7
通讯作者：
Kochs, E
中科院分区：
文献类型：
--
作者：
Lu, H;Werner, C;Kochs, E
在这项研究中，我们研究了七氟醚对大鼠脑血流量（CBF）自动调节的影响。将24只雄性Sprague-Dawley大鼠随机分配接受以下麻醉处理之一。在第1组（n = 8，对照）中，使用芬太尼（25 μ g . kg（-1）。h（-1））和N2 O/O-2（吸入氧分数0.33）。在第2组（n = 8）和第3组（n = 8）中，分别使用O-2/空气（吸入氧分数0.33）中的2%七氟烷（1最低肺泡麻醉浓度[MAC]）和2 MAC七氟烷（4 vol%）维持麻醉。在平均动脉压（MAP）范围为100-30 mm Hg的分级出血期间，使用激光多普勒血流仪测量皮质CBF自动调节。使用芬太尼/N2 O（第2组）和1 MAC七氟烷（第2组）时，CBF恒定，MAP范围为100-40 mm Hg。在第3组（2 MAC七氟烷）中，CBF下降为出血性低血压的线性函数。这些结果表明，在1 MAC七氟烷期间，CBF自动调节是完整的。相反，使用2 MAC七氟烷时，CBF自动调节受损。这可能与七氟烷浓度较高时基线脑血管张力降低有关，从而导致出血期间脑血管自动调节扩张能力降低。结论：七氟醚对大鼠脑血流自动调节有明显的影响。使用1个最小肺泡麻醉剂浓度的七氟烷时，脑血流自动调节完整，但使用2个最小肺泡麻醉剂浓度的七氟烷时，脑血流自动调节受损。
In this study, we investigated the effect of sevoflurane on cerebral blood flow (CBF) autoregulation in rats. Twenty-four male Sprague-Dawley rats were randomly assigned to receive one of the following anesthetic treatments. In Group 1 (n = 8, control) anesthesia was maintained using fentanyl (25 mu g . kg(-1) . h(-1)) and N2O/O-2 (fraction of inspired oxygen 0.33). In Group 2 (n = 8) and Group 3 (n = 8), anesthesia was maintained using 2% sevoflurane (1 minimum alveolar anesthetic concentration [MAC]) and 2 MAC sevoflurane (4 vol%) in O-2/air (fraction of inspired oxygen 0.33), respectively. Cortical CBF autoregulation was measured during graded hemorrhage within the mean arterial pressure (MAP) range of 100-30 mm Hg using laser Doppler flowmetry. CBF was constant with fentanyl/ N2O (Group 2) and 1 MAC sevoflurane (Group 2) within the MAP range of 100-40 mm Hg. In Group 3 (2 MAC sevoflurane), CBF decreased as a linear function of hemorrhagic hypotension. These results indicate that CBF autoregulation was intact during 1 MAC sevoflurane. In contrast, CBF autoregulation was impaired with 2 MAC sevoflurane. This is probably related to a reduction of baseline cerebrovascular tone with higher concentrations of sevoflurane, which results in a decreased capacity of autoregulatory cerebrovascular dilation during hemorrhage. Implications: The purpose of the present study was to investigate the effect of sevoflurane on cerebral blood flow autoregulation in rats. Cerebral blood flow autoregulation was intact with 1 minimum alveolar anesthetic concentration sevoflurane but was impaired with 2 minimum alveolar anesthetic concentration sevoflurane.