Prognostic value of cardiac risk factors and coronary artery calcium screening for all-cause mortality
Prognostic value of cardiac risk factors and coronary artery calcium screening for all-cause mortality
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DOI：
10.1148/radiol.2283021006
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发表时间：
2003-09-01
期刊：
影响因子：
19.7
通讯作者：
Callister, TQ
中科院分区：
文献类型：
--
作者：
Shaw, LJ;Raggi, P;Callister, TQ
目的：建立风险调整的多变量模型，包括危险因素和电子束CT测定的冠状动脉钙化积分，用于预测全因死亡率。材料和方法：我们跟踪观察了10,377名接受电子束CT心脏危险因素评估和冠状动脉钙化筛查的无症状个体。建立了预测全因死亡率的多变量Cox比例风险模型。结果：冠心病家族史(69%)、高胆固醇血症(62%)、高血压(44%)、吸烟(40%)和糖尿病(9%)等心脏危险因素普遍存在。冠状动脉钙化积分在10分以下、11~100分、101~400分、401~1000分和14%~6%、>1000分分别为57%、20%和3%。在平均随访5.0年+/-0.0086(平均值的标准误差)期间，死亡率为2.4%。在风险调整模型中(模型X_1(2)=388.2，P
PURPOSE: To develop risk-adjusted multivariable models that included risk factors and coronary calcium scores determined with electron-beam computed tomography (CT) in asymptomatic patients for the prediction of all-cause mortality.MATERIALS AND METHODS: We followed up a cohort of 10,377 asymptomatic individuals undergoing cardiac risk factor evaluation and coronary calcium screening with electron-beam CT. Multivariable Cox proportional hazards models were developed to predict all-cause mortality. Risk-adjusted models incorporated traditional risk factors for coronary disease and coronary calcium scores.RESULTS: Cardiac risk factors such as family history of coronary disease (69%), hypercholesterolemia (62%), hypertension (44%), smoking (40%), and diabetes (9%) were prevalent. The frequency of coronary calcium scores was 57%, 20%, and 3% for scores of 10 or less, 11-100, 101-400, 401-1,000, and 14% 6%,, greater than 1,000, respectively. During a mean follow-up of 5.0 years +/- 0.0086 (standard error of the mean), the death rate was 2.4%. In a risk-adjusted model (model chi(2) = 388.2, P