Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).
Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).
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冠心病高发区（芬兰北卡累利阿）的家族聚集性。
DOI：
10.1136/hrt.42.3.294
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发表时间：
1979
影响因子：
--
通讯作者：
A. Rissanen
中科院分区：
文献类型：
--
作者：
A. Rissanen
在东芬兰的211名56岁以下男性的家庭中评估了冠心病的发生率。50名近期心肌梗死的幸存者，55名死于心肌梗死，53名患有单纯性心绞痛，53名为健康参考男性。冠心病的总体患病率在所有病例先证者的家族中相似。到70岁时，病例父亲死于冠心病的累积风险（36%的机会）比参考父亲高6倍，而病例母亲和参考母亲之间只有很小的差异。与参照同胞相比，病例兄弟（70%）和病例姐妹篇（40%）在65岁时发生致死性或非致死性冠心病的累积风险分别为4.5倍和2.6倍。风险是最大的情况下同胞与父母，特别是母亲，历史的早发冠心病。冠心病的临床表现在同胞中表现出相似性。心源性死亡在致命性心肌梗死先证者的同胞中最常见，而心绞痛在心绞痛先证者的同胞中最常见。
Occurrence of coronary heart disease was assessed in families of 211 men under the age of 56 from East Finland. Fifty men were survivors of recent myocardial infarctions, 55 had died of myocardial infarction, 53 suffered from uncomplicated angina pectoris, and 53 were healthy reference men. Overall prevalence of coronary heart disease was similar in familes of all case probands. By age 70, case fathers had a 6 times greater cumulative risk (a 36% chance) of dying from coronary heart disease than reference fathers, whereas there was only a small difference between case and reference mothers. Cumulative risk of developing fatal or non-fatal coronary heart disease by age 65 was 4.5-fold for case brothers (70%) and 2.6-fold for case sisters (40%), when compared with reference sibs. The risk was greatest for case sibs with a parental, especially a maternal, history of premature coronary heart disease. Clinical manifestations of coronary heart disease showed similarities within sibships. Cardiac deaths were commonest in sibs of the fatal myocardial infarction probands, whereas angina was commonest in sibs of the angina pectoris probands.