Delta sleep EEG in depressed adolescent females and healthy controls
Delta sleep EEG in depressed adolescent females and healthy controls
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DOI：
10.1016/s0165-0327(00)00194-4
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发表时间：
2001-03-01
影响因子：
6.6
通讯作者：
Rush, AJ
中科院分区：
文献类型：
--
作者：
Armitage, R;Emslie, GJ;Rush, AJ
背景资料：定量脑电图研究已经确定了一些严重抑郁症（MDD）成人的睡眠异常，包括在NREM;I睡眠期间δ活动的幅度减少。迄今为止，这些方法尚未用于早发性R-IDD。研究方法：研究人员比较了8名有症状但未经药物治疗的MDD青少年女性和8名年龄和性别匹配的健康对照者在NREM睡眠期间的δ活动。结果：抑郁组在第一个NREM睡眠期的δ振幅和功率显著降低。相比之下，标准的睡眠结构并没有区分各组。局限性：鉴于样本量，本研究最好被视为试验性研究。此外，尚未确定患有MDD的青少年男性是否也表现出δ睡眠异常。此外，未能发现组间REM潜伏期或其他宏观结构指标的差异可能是由于样本量小。结论：本研究的结果强调了定量睡眠脑电图技术在早发性MDD中的实用性。然而，本研究的结果与成人MDD的报告不同，其中δ异常在男性中更普遍。这些研究结果表明，成熟的睡眠脑电图干扰的时间过程可能会有所不同，男性和女性抑郁症。抑郁症早期出现的δ异常可能与临床病程有关。(C)2001 Elsevier Science B. V.保留所有权利。
Background: Quantitative EEG studies have identified a number of sleep abnormalities in adults with major depressive disorders (MDD), including a reduction in the amplitude of delta activity during NREM;I sleep. To date, these methodologies have not been used in early onset R-IDD. Methods: Delta activity during NREM sleep was compared in eight symptomatic but unmedicated adolescent females with MDD and eight age- and gender-matched healthy controls. Results: The depressed group showed significantly lower delta amplitude and power in the first NREM sleep period. By contrast, standard sleep architecture did not differentiate between groups. Limitations: Given the sample size, this study is best viewed as tentative. In addition, it has yet to be determined whether adolescent males with MDD also show delta sleep abnormalities. Further, failure to find between-group differences in REM latency or other macroarchitectural measures may be due to the small sample size. Conclusions: The findings of this study underscore the utility of quantitative sleep EEG techniques in early onset MDD. The results of the present study do, however, diverge from reports in adults with MDD, where delta abnormalities are more prevalent in men. Such findings suggest that the maturational time course of sleep EEG disturbances may differ for males and females with depression. Early emergence of delta abnormalities in depression may be of relevance to clinical course of illness. (C) 2001 Elsevier Science B.V. All rights reserved.