The Effects of Hyper- and Hypocapnia on Phonatory Laryngeal Airway Resistance in Women.
The Effects of Hyper- and Hypocapnia on Phonatory Laryngeal Airway Resistance in Women.
复制标题
高碳酸血症和低碳酸血症对女性发声喉气道阻力的影响。
DOI：
10.1044/2015_jslhr-s-13-0270
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
VerdoliniAbbott,Katherine
中科院分区：
文献类型：
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作者：
Gillespie,AmandaI;Slivka,William;AtwoodJr,CharlesW;VerdoliniAbbott,Katherine
目的喉在调节气体流入和流出肺部方面具有双重作用，同时也建立了声带振动所需的阻力。本研究评估发音功能之间的相互关系，特别是，发音喉气道阻力（Rlaw）-和呼吸稳态在状态的发音气体perturbation.MethodTwenty-four健康女性进行发音任务，同时暴露于诱导高碳酸血症（高CO2），低碳酸血症（低CO2），和正常呼吸（eupnea）。气体扰动对Rlaw的影响进行了研究，作为Rlaw modulations对呼吸homeostasis. ResultsRlaw保持稳定，尽管操作的吸入气体浓度的相互影响。相反，潮气末CO2水平在所有发声任务中显著增加。因此，对于测试的条件，Rlaw并没有像预测的那样调整以适应解释性需求。相反，稳定的Rlaw是以牺牲这些需求为代价而自发实现的。结论研究结果为调节理论提供了支持，其中Rlaw可能是发声的控制参数。结果也提供了深入了解发声对呼吸的影响。这项工作为将来研究下呼吸道疾病患者和其他患者群体发声过程中的喉功能奠定了基础。
PurposeThe larynx has a dual role in the regulation of gas flow into and out of the lungs while also establishing resistance required for vocal fold vibration. This study assessed reciprocal relations between phonatory functions—specifically, phonatory laryngeal airway resistance (Rlaw)—and respiratory homeostasis during states of ventilatory gas perturbations.MethodTwenty-four healthy women performed phonatory tasks while exposed to induced hypercapnia (high CO2), hypocapnia (low CO2), and normal breathing (eupnea). Effects of gas perturbations on Rlawwere investigated as were the reciprocal effects of Rlawmodulations on respiratory homeostasis.ResultsRlawremained stable despite manipulations of inspired gas concentrations. In contrast, end-tidal CO2levels increased significantly during all phonatory tasks. Thus, for the conditions tested, Rlawdid not adjust to accommodate ventilatory needs as predicted. Rather, stable Rlawwas spontaneously accomplished at the cost of those needs.ConclusionsFindings provide support for a theory of regulation wherein Rlawmay be a control parameter in phonation. Results also provide insight into the influence of phonation on respiration. The work sets the foundation for future studies on laryngeal function during phonation in individuals with lower airway disease and other patient populations.