EFFECTOR FUNCTIONS OF EOSINOPHILS IN SCHISTOSOMIASIS
EFFECTOR FUNCTIONS OF EOSINOPHILS IN SCHISTOSOMIASIS
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DOI：
10.1590/s0074-02761992000800025
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发表时间：
1992-01-01
影响因子：
2.8
通讯作者：
CAPRON, A
中科院分区：
文献类型：
--
作者：
CAPRON, M;CAPRON, A
嗜酸性粒细胞的双重功能在血吸虫病中得到了清楚的体现。嗜酸性粒细胞具有良好的免疫球蛋白和补体膜受体，并且由于颗粒碱性蛋白的存在，可以对寄生虫幼虫产生细胞毒性，从而参与保护性免疫。然而，介质也可以对正常细胞或组织发挥其细胞溶解作用，从而诱发病理。通过涉及不同抗体同种型（IgG、IgE 和 IgA）的体外针对血吸虫幼虫的 ADCC 机制以及在体内进行的实验，嗜酸性粒细胞明显参与了保护性免疫。尽管没有直接证据表明嗜酸性粒细胞在人类中具有保护作用，但嗜酸性粒细胞依赖性细胞毒性抗体同种型与抗再感染性（例如 IgE 和 IgA 抗体）之间存在惊人的关联，而在易感受试者中检测到体外阻断抗体同种型（IgG4、IgM），强烈表明嗜酸性粒细胞参与了抗体依赖性保护性免疫反应。然而，嗜酸性粒细胞也可能参与曼氏血吸虫卵周围肉芽肿的形成，从而参与血吸虫病引起的病理反应。
The dual function of eosinophils is clearly illustrated in schistosomiasis. Well equipped in membrane receptors for immunoglobulins and complement, and due to the presence of granule basic proteins, eosinophils can becone cytotoxic for parasite larvae and thus participate to protective immunity. However mediators can also exert their cytolytic effect on normal cells or tissues, inducing therefore pathology. Through ADCC mechanisms against schistosome larvae in vitro involving different antibody isotypes (IgG, IgE and IgA) and also in experiments performed in vivo, eosinophils have been clearly involved in protective immunity.Although no direct evidence of the protective role of eosinophils were brought in humans, the striking association of eosinophil-dependent cytotoxic antibody isotypes with resistance to reinfection (for instance IgE and IgA antibodies), whereas in vitro blocking antibody isotypes (IgG4, IgM) were detected in susceptible subjects, strongly, suggested the participation of eosinophils in antibody-dependent protective immune response. However eosinophils could also participate to granuloma formation around S. mansoni eggs and consequently to the pathological reactions induced by schistosomiasis.