A potential revolution in cancer treatment: A topical review of FLASH radiotherapy.
A potential revolution in cancer treatment: A topical review of FLASH radiotherapy.
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DOI：
10.1002/acm2.13790
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发表时间：
2022-10
影响因子：
2.1
通讯作者：
Yang, Xiaofeng
中科院分区：
文献类型：
--
作者：
Gao, Yuan;Liu, Ruirui;Chang, Chih-Wei;Charyyev, Serdar;Zhou, Jun;Bradley, Jeffrey D.;Liu, Tian;Yang, Xiaofeng
FLASH放疗（RT）是一种超高剂量率（UHDR）（≥40 Gy/s）给药至整个治疗体积的新技术。最近的体内研究结果表明，UHDR RT有可能在不牺牲肿瘤控制的情况下保留正常组织。人们对FLASH RT的应用越来越感兴趣，一些实验和改进的线性加速器已经实现了超高剂量的照射递送。FLASH效应的潜在机制尚不完全清楚，但正常组织中的氧消耗在FLASH照射期间提供额外的保护是目前最受关注的假设。蒙特卡罗模拟在FLASH中发挥着重要作用，使人们能够理解其剂量学计算和硬件设计。更先进的蒙特卡罗模拟工具正在开发中，以满足在FLASH照射中再现放射溶解和放射生物学过程的挑战。FLASH RT可能成为未来肿瘤治疗的标准治疗方式之一。本文介绍了FLASH RT研究的历史和现状，重点介绍了FLASH辐照传递方式、FLASH效应的潜在机制、体内和体外实验以及模拟研究。本文讨论了该新技术存在的挑战和前景。
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR) (≥40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies show that the UHDR RT has the potential to spare normal tissue without sacrificing tumor control. There is a growing interest in the application of FLASH RT, and the ultrahigh dose irradiation delivery has been achieved by a few experimental and modified linear accelerators. The underlying mechanism of FLASH effect is yet to be fully understood, but the oxygen depletion in normal tissue providing extra protection during FLASH irradiation is a hypothesis that attracts most attention currently. Monte Carlo simulation is playing an important role in FLASH, enabling the understanding of its dosimetry calculations and hardware design. More advanced Monte Carlo simulation tools are under development to fulfill the challenge of reproducing the radiolysis and radiobiology processes in FLASH irradiation. FLASH RT may become one of standard treatment modalities for tumor treatment in the future. This paper presents the history and status of FLASH RT studies with a focus on FLASH irradiation delivery modalities, underlying mechanism of FLASH effect, in vivo and vitro experiments, and simulation studies. Existing challenges and prospects of this novel technique are discussed in this manuscript.
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DOI：
10.1016/s0360-3016(01)01630-3
发表时间：
2001-10-01
影响因子：
7
作者：
Brizel, DM;Schroeder, T;Mueller-Klieser, W
通讯作者：
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DOI：
10.1016/j.ijrobp.2021.03.056
发表时间：
2021-09-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
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作者：
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影响因子：
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影响因子：
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影响因子：
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作者：
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