Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: ductular cells, including islet cell precursors, as primary progenitor cells of tumors.
Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: ductular cells, including islet cell precursors, as primary progenitor cells of tumors.
复制标题
胰岛细胞作为胰腺导管肿瘤的组成部分。
作者：
P. Pour
叙利亚仓鼠胰腺的导管复合体代表了一个导管系统，包括闰（小叶内）、岛周和岛内导管。闰管由腺泡中心细胞和闰管细胞组成。小导管网（通常组织学检查不可见）围绕胰岛（岛周导管），并以通常分叉的微小通道形式在胰岛内延伸（岛内导管）。虽然后者的小管的功能是模糊的，它们的细胞似乎构成了胰腺的未分化细胞单位之一，因此也是胰岛β细胞的祖细胞（胰岛细胞前体= IP）。系统的胰腺组织学检查，在这个物种与胰腺致癌物N-亚硝基双（2-氧代丙基）胺治疗表明，导管细胞，特别是那些岛周和岛内起源，是最敏感的这种致癌物。肿瘤过程始于与新形成的胰岛相关的闰（小叶内）导管和小叶间导管细胞增生（胰岛母细胞增多症）。这一过程之后是过度形成的成熟，但特别是未成熟的胰岛细胞及其前体（IP）在胰岛外周，以及与外观，扩张，和增殖的岛周，特别是岛内小管。这些岛周和岛内小管（包括IP）的增生、化生和恶性改变，以及较小程度的闰管的增生、化生和恶性改变表明它们的组织发生关系和它们在致癌刺激下再生胚胎组织的潜力。一些诱发性病变与糖尿病的相似性已被强调。
The ductular complex of the Syrian hamster pancreas represents a system of conduit which encompasses intercalated (intralobular), periinsular, and intrainsular ductules. The intercalated (intralobular) ductules comprise centroacinar and intercalated cells. A meshwork of small ductules (invisible by usual histologic procedures) surrounds islets (periinsular ductules) and extends in the form of often ramified tiny channels within the islet (intrainsular ductules). Although the function of the latter ductules is obscure, their cells seem to make up one of the undifferentiated cellular units of the pancreas, and as such are also the progenitors of beta-cells of the islets (islet cell precursor = IP). Systematic histologic examination of the pancreas in this species treated with pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine indicated that ductular cells, especially those of periinsular and intrainsular origin, are the most responsive to this carcinogen. The neoplastic process was initiated with hyperplasia of intercalated (intralobular) ductular and interlobular ductal cells associated with newly formed islets (nesidioblastosis). This process was followed by excess formation of mature but especially of immature islet cells and their precursors (IP) in the islet periphery, as well as with the appearance, distention, and multiplication of periinsular and particularly of intrainsular ductules. The hyperplasia, metaplasia, and malignant alteration of these periinsular and intrainsular ductules (including IP) and, to a lesser degree, of intercalated ductules indicated their histogenetic relationship and their potency for reproducing embryonic tissue on carcinogenic stimulus. The similarity of some induced lesions to diabetes has been emphasized.