iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation.
iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation.
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DOI：
10.1038/hgv.2018.8
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发表时间：
2018
影响因子：
1.5
通讯作者：
Shimizu A
中科院分区：
文献类型：
--
作者：
Komaki S;Shiwa Y;Furukawa R;Hachiya T;Ohmomo H;Otomo R;Satoh M;Hitomi J;Sobue K;Sasaki M;Shimizu A
我们启动了一个综合性多组学数据库iMETHYL（imethyl.iwate-megabank.org）。iMETHYL提供了从大约100名受试者中收集的CD4+ T淋巴细胞、单核细胞和中性粒细胞的全DNA甲基化（约2400万个常染色体CpG位点）、全基因组（约900万个单核苷酸变体）和全转录组（> 14000个基因）数据。这些数据来自全基因组亚硫酸氢盐测序、全基因组测序和全转录组测序，使iMETHYL成为一个全面的数据库。
We launched an integrative multi-omics database, iMETHYL (http://imethyl.iwate-megabank.org). iMETHYL provides whole-DNA methylation (~24 million autosomal CpG sites), whole-genome (~9 million single-nucleotide variants), and whole-transcriptome (>14 000 genes) data for CD4+ T-lymphocytes, monocytes, and neutrophils collected from approximately 100 subjects. These data were obtained from whole-genome bisulfite sequencing, whole-genome sequencing, and whole-transcriptome sequencing, making iMETHYL a comprehensive database.