Endovascular Ischemic Stroke Models in Nonhuman Primates
Endovascular Ischemic Stroke Models in Nonhuman Primates
复制标题
非人灵长类血管内缺血性卒中模型的建立
DOI：
10.1007/s13311-017-0586-z
复制
发表时间：
2017
影响因子：
5.7
通讯作者：
Di Wu;Ankush Chandra;Jian Chen;Yuchuan Ding;X. Ji
中科院分区：
文献类型：
--
作者：
Di Wu;Ankush Chandra;Jian Chen;Yuchuan Ding;X. Ji
To bridge the gap between rodent and human studies, the Stroke Therapy Academic Industry Roundtable committee suggests that nonhuman primates (NHPs) be used for preclinical, translational stroke studies. Owing to the fact that vast majority of ischemic strokes are caused by transient or permanent occlusion of a cerebral blood vessel eventually leading to brain infarction, ischemia induced by endovascular methods closely mimics thromboembolic or thrombotic cerebrovascular occlusion in patients. This review will make a thorough summary of transient or permanent occlusions of a cerebral blood vessel in NHPs using endovascular methods. Then, advantages and disadvantages, and potential applications will be analyzed for each kind of models. Additionally, we also make a further analysis based on different kinds of emboli, various occlusion sites, infract size, abnormal hemodynamics, and potential dysfunctions. Experimental models of ischemic stroke in NHPs are valuable tools to analyze specific facets of stroke in patients, especially those induced by endovascular methods.
