MR perfusion imaging in acute ischemic stroke.
MR perfusion imaging in acute ischemic stroke.
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DOI：
10.1016/j.nic.2011.02.007
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发表时间：
2011-05
影响因子：
2.3
通讯作者：
Wu O
中科院分区：
文献类型：
--
作者：
Copen WA;Schaefer PW;Wu O
磁共振灌注成像提供了测量急性脑卒中患者脑灌注的潜力，在基于这些测量的治疗决策可能会显著影响结果的时候。急性脑卒中治疗和灌注成像技术的快速发展导致灌注成像在患者管理中应发挥的作用不断重新定义。本综述首先讨论了急性卒中的基本病理生理，特别关注MR灌注成像可以研究的各种灌注相关参数的改变。虽然这些参数有时被认为是可以互换的，但它们显示的脑灌注信息却有很大的不同。因此，对不同类型灌注图像的效用的后续讨论侧重于它们之间的差异，以及可能使其解释复杂化的重要伪影。最后，总结了磁共振灌注成像在急性脑卒中治疗中不断发展的作用。
MR perfusion imaging offers the potential for measuring brain perfusion in acute stroke patients, at a time when treatment decisions based upon these measurements may affect outcomes dramatically. Rapid advancements in both acute stroke therapy and perfusion imaging techniques have resulted in continuing redefinition of the role that perfusion imaging should play in patient management. This review first discusses the basic pathophysiology of acute stroke, with specific attention to alterations in the various perfusion-related parameters that can be studied by MR perfusion imaging. Although these parameters are sometimes treated as somewhat interchangeable, they reveal greatly different information about brain perfusion. Therefore, subsequent discussion of the utility of different kinds of perfusion images focuses on the differences between them, as well as important artifacts that can complicate their interpretation. Finally, research on the continually evolving role of MR perfusion imaging in acute stroke care is summarized.