A MOUSE MODEL OF THE RECRUDESCENCE OF LATENT TUBERCULOSIS IN THE ELDERLY
A MOUSE MODEL OF THE RECRUDESCENCE OF LATENT TUBERCULOSIS IN THE ELDERLY
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DOI：
10.1164/ajrccm/137.3.716
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发表时间：
1988-03-01
期刊：
影响因子：
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通讯作者：
ORME, IM
中科院分区：
文献类型：
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作者：
ORME, IM
本研究旨在通过观察3月龄小鼠暴露于低剂量结核分枝杆菌Erdman气雾剂后的感染过程，试图建立一种肺结核复发的动物模型。结果表明，这些小鼠死于压倒性肺病的平均年龄为24个月；相比之下，未感染的小鼠多活了4到6个月。对20到24个月大的受感染小鼠的检查提供了证据，表明在这段时间内复发是受感染小鼠中的一个普遍现象，其特征是肺部细菌数量从每只动物大约104个增加到108个。旨在调查这种复发的潜在基础的实验表明，与暴露于类似产气剂量的年轻小鼠相比，这些动物对感染的获得性免疫的能力随着年龄的增长而大幅下降。因此，数据表明，老年小鼠肺结核的“自发”复发反映了它们无法回忆起对再次出现的感染的记忆获得性免疫。
The present study was designed to attempt to construct an animal model of the recrudescence of pulmonary tuberculosis by following the course of infection in mice exposed at 3 months of age to a low dose aerosol of Mycobacterium tuberculosis Erdman. The results show that such mice died of overwhelming lung disease at a median age of 24 months; in contrast, uninfected mice lived 4 to 6 months longer. Examination of infected mice over the period of 20 to 24 months of age provided evidence to suggest that recrudescence over this period of time was a general phenomenon within the infected mice, and was characterized by increases in lung bacterial numbers from approximately 104 to 108 organisms per animal. Experiments designed to investigate the underlying basis of this recrudescence revealed that the capacity of the old mice to mount acquired immunity to the infection exhibited a substantial age-related decline in these animals when compared with young mice exposed to similar aerogenic doses. The data suggest, therefore, that "spontaneous" recrudescence of pulmonary tuberculosis in old mice reflects their inability to recall anamnestic acquired immunity to the reemerging infection.