Structural atlas of dynein motors at atomic resolution
Structural atlas of dynein motors at atomic resolution
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DOI：
10.1007/s12551-018-0402-y
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发表时间：
2018-02
影响因子：
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通讯作者：
Akiyuki Toda;Hideaki Tanaka;G. Kurisu
中科院分区：
文献类型：
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作者：
Akiyuki Toda;Hideaki Tanaka;G. Kurisu
动力蛋白马达是生物学上重要的生物纳米机器，来自不同生物体的细胞质动力蛋白成分的许多原子分辨率结构已经通过x射线晶体学，冷冻电镜和核磁共振光谱分析。本文综述了细胞质和轴突动力蛋白及其附属蛋白结构研究的历史进展。我们描述了动力蛋白每个组成部分的代表性结构研究，并将其总结为细胞质和轴突动力蛋白分类的结构图谱。基于我们对蛋白质数据库中所有动力蛋白结构的回顾，我们提出了理解两种类型动力蛋白马达的两个要点，并讨论了未来结构研究的潜在前景。
Dynein motors are biologically important bio-nanomachines, and many atomic resolution structures of cytoplasmic dynein components from different organisms have been analyzed by X-ray crystallography, cryo-EM, and NMR spectroscopy. This review provides a historical perspective of structural studies of cytoplasmic and axonemal dynein including accessory proteins. We describe representative structural studies of every component of dynein and summarize them as a structural atlas that classifies the cytoplasmic and axonemal dyneins. Based on our review of all dynein structures in the Protein Data Bank, we raise two important points for understanding the two types of dynein motor and discuss the potential prospects of future structural studies.