Noninvasive Electrical Mapping Compared with the Paced QRS Complex for Optimizing CRT Programmed Settings and Predicting Multidimensional Response.
Noninvasive Electrical Mapping Compared with the Paced QRS Complex for Optimizing CRT Programmed Settings and Predicting Multidimensional Response.
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DOI：
10.1007/s12265-023-10418-1
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发表时间：
2023-12
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
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作者：
目的是检验以下假设：通过体表电标测（美敦力CardioInsight 252电极背心）对左心室（LV）和右心室（RV）激动情况进行检测，可确定30例患者的最佳心脏再同步化治疗（CRT）起搏策略及治疗效果。LV80、RV80和BIV80分别定义为达到80%左心室、右心室或双心室电激动的时间。同步左心室起搏时LV80和RV80的差值（|LV80 - RV80|）较小，预示CRT术后左心室功能更好（p = 0.0004），而左心室起搏的QRS波持续时间则无此效果（p = 0.32）。同样，RV80较低与心脏磁共振（CMR）检测的CRT术前右心室射血分数较好相关（r = -0.40，p = 0.04），且对CRT术后心肌摄氧量改善的预测效果优于双心室起搏的QRS波（p = 0.01对p = 0.38），而双心室起搏时LV80较低预示CRT术后B型利钠肽（BNP）较低（p = 0.02）。右心室起搏在|LV80 - RV80|较小时可改善左心室功能（p = 0.009）。总之，三维电标测可预测CRT术后良好的治疗效果，并为有效的起搏策略提供依据。
网络版包含补充材料，网址为10.1007/s12265 - 023 - 10418 - 1。
The aim was to test the hypothesis that left ventricular (LV) and right ventricular (RV) activation from body surface electrical mapping (CardioInsight 252-electrode vest, Medtronic) identifies optimal cardiac resynchronization therapy (CRT) pacing strategies and outcomes in 30 patients. The LV80, RV80, and BIV80 were defined as the times to 80% LV, RV, or biventricular electrical activation. Smaller differences in the LV80 and RV80 (|LV80-RV80|) with synchronized LV pacing predicted better LV function post-CRT (p = 0.0004) than the LV-paced QRS duration (p = 0.32). Likewise, a lower RV80 was associated with a better pre-CRT RV ejection fraction by CMR (r = − 0.40, p = 0.04) and predicted post-CRT improvements in myocardial oxygen uptake (p = 0.01) better than the biventricular-paced QRS (p = 0.38), while a lower LV80 with BIV pacing predicted lower post-CRT B-type natriuretic peptide (BNP) (p = 0.02). RV pacing improved LV function with smaller |LV80-RV80| (p = 0.009). In conclusion, 3-D electrical mapping predicted favorable post-CRT outcomes and informed effective pacing strategies. The online version contains supplementary material available at 10.1007/s12265-023-10418-1.
影响因子：
4.6
作者：
Fernandez, Juan M. F.;Spagnuolo, Damian N.;Politi, Maria T.;Tello Santacruz, Ivan A.;Schiavone, Miguel;Caceres Monie, Cesar;Avaca, Horacio A.;Chara, Osvaldo
通讯作者：
Chara, Osvaldo
影响因子：
4.8
作者：
Bilchick KC;Stafford P;Laja O;Elumogo C;Bediako P;Tolbert N;Sawch D;David S;Sodhi N;Barber A;Kwon Y;Mehta N;Patterson B;Breathett K;Mazimba S
通讯作者：
Mazimba S
影响因子：
3.6
作者：
通讯作者：
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