Photoperiodic regulation of pulsatile luteinizing hormone secretion and adenohypophyseal gene expression in female golden hamsters.
Photoperiodic regulation of pulsatile luteinizing hormone secretion and adenohypophyseal gene expression in female golden hamsters.
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雌性金仓鼠脉动黄体生成素分泌和腺垂体基因表达的光周期调节。
DOI：
10.1095/biolreprod47.1.66
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发表时间：
1992
影响因子：
3.6
通讯作者：
Hegarty,CM
中科院分区：
文献类型：
--
作者：
Bittman,EL;Jonassen,JA;Hegarty,CM
LH浓度测定血清中收集在10毫米的时间间隔，从长期卵巢切除雌性叙利亚仓鼠已维持9周的刺激（长）或抑制（短）photopenods。短日照减少了早上和下午可检测到的LH脉冲的数量。大多数短日照仓鼠的血清LH浓度在下午逐渐升高;这种升高不是由多次脉冲组成的。在单独的类似处理的仓鼠组，垂体LH-β mRNA丰度显着减少短日暴露在一天中的两个时间，即使血清LH浓度在下午上升。雌激素处理诱导下午血清LH激增，在两个光周期，并消除了LH-β mRNA丰度在下午的光周期的影响。血清催乳素（PRL）浓度并不一致的影响，白天长度在去势仓鼠与雌激素治疗或不治疗，但PRL mRNA丰度显着抑制短日暴露在所有组。结果表明，白天长度对垂体基因表达产生深刻的类固醇非依赖性影响，LH-β mRNA丰度的调节可能是由于神经GnRH脉冲发生器的光周期控制。
LH concentrations were measured in serum collected at 10-mm intervals from chronically ovariectomized female Syrian hamsters that had been maintained for 9 wk in stimulatory (long) or inhibitory (short) photopenods. Short days reduced the number of detectable LH pulses during both the morning and the afternoon. Most short-day hamsters experienced a gradual afternoon rise in serum LH concentrations; this rise was not composed of multiple pulses. In separate groups of similarly treated hamsters, pituitary LH-beta mRNA abundance was significantly reduced by short-day exposure at both times of day even though serum LH concentrations rose in the afternoon. Estradiol treatment induced an afternoon surge of serum LH in both photoperiods, and eliminated the effect of photoperiod on LH-beta mRNA abundance in the afternoon. Serum prolactin (PRL) concentrations were not consistently influenced by day length in castrated hamsters with or without estrogen treatment, but PRL mRNA abundance was significantly suppressed by short-day exposure in all groups. The results indicate that day length exerts profound steroidindependent effects upon hypophyseal gene expression, and that the regulation of LH-beta mRNA abundance may be due to photoperiodic control of the neural GnRH pulse generator.
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