QRS transitional zone rotations and the risk of atrial fibrillation: the Suita Study.
QRS transitional zone rotations and the risk of atrial fibrillation: the Suita Study.
复制标题
QRS 过渡区旋转和心房颤动的风险：吹田研究。
DOI：
10.1007/s00380-022-02101-3
复制
发表时间：
2022
影响因子：
1.5
通讯作者：
Kusano K.
中科院分区：
文献类型：
--
作者：
Arafa A;Kokubo Y;Kobayashi T;Honda-Kohmo K;Kashima R;Sheerah HA;Kusano K.
心电图筛查可以检测出有发生房颤（AF）风险的人。最近的文献表明，QRS移行带旋转可以预测几种心血管事件。在此，我们调查了QRS移行区旋转与未来房颤风险之间的关系。这项前瞻性队列研究包括来自日本吹田市的6794名参与者（3178名男性和3616名女性），年龄在30-84岁之间。QRS移行带旋转在基线期间通过ECG诊断，而AF在随访期间通过ECG、医院记录和检查诊断。使用考克斯回归计算与正常旋转受试者相比，QRS移行区逆时针和顺时针旋转受试者发生AF的性别特定风险比（HR）和95%置信区间（CI）。在14.6年的中位随访期内，311名参与者在年龄校正模型中，逆时针旋转与男性AF风险降低相关，但与女性无关：HR（95%CI）= 0.66（0.44，0.98）和多变量校正模型：HR（95% CI）= 0.65（0.43，0.97）。在两种性别中，肱骨旋转与房颤风险无关。据我们所知，这是第一项研究表明逆时针旋转可能与男性房颤风险降低有关。需要更多的研究来证实我们的发现并阐明可能的机制。
ECG screening can detect people at risk of developing atrial fibrillation (AF). Recent literature indicated that QRS transitional zone rotations could predict several cardiovascular events. Herein, we investigated the association between QRS transitional zone rotations and the future risk of AF. This prospective cohort study included 6794 participants (3178 men and 3616 women), aged 30–84 years, from the urban Japanese city of Suita. QRS transitional zone rotations were diagnosed by ECG during baseline, while AF was diagnosed by ECG, hospital records, and checkups during follow-up. The Cox regression was used to compute the sex-specified hazard ratios (HRs) and 95% confidence intervals (CIs) of incident AF for participants with counterclockwise and clockwise QRS transitional zone rotations compared to those with normal rotation. Within a median follow-up period of 14.6 years, 311 participants (206 men and 105 women) developed AF. Counterclockwise rotation was associated with the reduced risk of AF among men, but not women, in the age-adjusted model: HR (95% CI) = 0.66 (0.44, 0.98) and the multivariable-adjusted model: HR (95% CI) = 0.65 (0.43, 0.97). Clockwise rotation was not associated with AF risk in either sex. To the best of our knowledge, this is the first study to indicate that counterclockwise rotation could be associated with the reduced risk of AF in men. More studies are needed to confirm our findings and elucidate possible mechanisms.