Construction of chitosan/Ag nanocomposite sponges and their properties
Construction of chitosan/Ag nanocomposite sponges and their properties
复制标题
壳聚糖/银纳米复合海绵的构建及其性能
DOI：
10.1016/j.ijbiomac.2021.10.011
复制
发表时间：
2021
影响因子：
8.2
通讯作者：
Lei Shi
中科院分区：
文献类型：
--
作者：
Panghu Zhou;Zunen Xia;Chao Qi;Meng He;Tengbo Yu;Lei Shi
将壳聚糖水凝胶浸泡在AgNO 3水溶液中，在80 °C下加热，在多孔壳聚糖基质中合成Ag纳米粒子（AgNPs），冷冻干燥，制备壳聚糖/Ag纳米复合海绵。采用红外光谱、X射线衍射、扫描电镜和压缩测试等手段对复合海绵的结构和性能进行了表征。本研究利用壳聚糖水凝胶的微孔作为微反应器，合成了能够均匀分布在壳聚糖基体上的银纳米粒子。壳聚糖/银纳米复合海绵具有良好的机械性能，适当的水蒸气传输和无细胞毒性。抑菌试验表明，它们对金黄色葡萄球菌和大肠杆菌有较好的抑菌活性。杆菌壳聚糖/银纳米复合海绵由于其良好的性能和易于工业化，在伤口敷料方面具有很大的潜力。
Chitosan/Ag nanocomposite sponges were prepared by soaking the chitosan hydrogels in AgNO3aqueous solution, which was heated at 80 °C to synthesize Ag nanoparticles (AgNPs) in the porous chitosan matrix and freeze-dried. The structure and properties of the nanocomposite sponges were characterized by FT-IR, X-ray diffraction (XRD), scanning electron microscopy (SEM), and compressive testing. In our findings, the pores of the chitosan hydrogel were used as a microreactor to synthesize AgNPs, which could distribute evenly on the chitosan matrix. The chitosan/Ag nanocomposite sponges exhibited good mechanical properties, suitable water vapor transmission and noncytotoxicity. Antibacterial test revealed their excellent antibacterial activity againstStaphylococcus aureusandE. coli. The chitosan/Ag nanocomposite sponges would have great potential as wound dressings due to their good properties and facile industrialization.