QUANTITATIVE DIFFERENCES IN THE DEPOSITION OF BETA A4 PROTEIN IN THE SULCI AND GYRI OF FRONTAL AND TEMPORAL ISOCORTEX IN ALZHEIMERS-DISEASE
QUANTITATIVE DIFFERENCES IN THE DEPOSITION OF BETA A4 PROTEIN IN THE SULCI AND GYRI OF FRONTAL AND TEMPORAL ISOCORTEX IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0304-3940(92)90639-o
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发表时间：
1992-02-17
影响因子：
2.5
通讯作者：
ROBERTS, GW
中科院分区：
文献类型：
--
作者：
GENTLEMAN, SM;ALLSOP, D;ROBERTS, GW
采用免疫组织化学和计算机图像分析相结合的方法，研究了14例阿尔茨海默病患者额叶和颞叶等皮质中β-淀粉样蛋白(β-A4)的分布。确定被β-A4沉积覆盖的皮质面积，并以每一感兴趣区皮质灰质总面积的百分比表示。脑沟灰质中的β-A4含量明显高于额叶和颞叶的脑回顶(P<；0.05)。此外，在每种情况下，在额叶而不是在颞叶观察到更多的β-A4。这种明显的不同脆弱性可能反映了潜在的解剖联系或细胞堆积密度的差异，似乎加强了疾病病理传播的解剖学基础的理由。
The distribution of beta-amyloid protein (beta-A4) in the frontal and temporal isocortex of 14 Alzheimer's disease brains was examined using a combination of immunohistochemistry and computer image analysis. The area of cortex covered by beta-A4 deposits was determined and expressed as a percentage of the total cortical grey matter area in each field of interest. Significantly more beta-A4 was found in the grey matter of the sulci as compared to that of the gyral crests in both the frontal and the temporal lobes (P < 0.05). Furthermore, in each case, greater quantities of beta-A4 were observed in the frontal rather than the temporal lobes. This apparent differential vulnerability is likely to reflect underlying anatomical connections or perhaps differences in cell packing density and appears to strengthen the case for an anatomical basis for the spread of the disease pathology.