Malignant peripheral nerve sheath tumors presenting as spinal dumbbell tumors: clinical outcomes and characteristic imaging features
Malignant peripheral nerve sheath tumors presenting as spinal dumbbell tumors: clinical outcomes and characteristic imaging features
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DOI：
10.1007/s00586-014-3467-8
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发表时间：
2015-10-01
影响因子：
2.8
通讯作者：
Iwamoto, Yukihide
中科院分区：
文献类型：
--
作者：
Matsumoto, Yoshihiro;Endo, Makoto;Iwamoto, Yukihide
目的探讨以脊髓哑铃型肿瘤为表现的恶性周围神经鞘膜瘤（MPNSTs）的临床和影像学特征。方法回顾性分析8例脊髓哑铃型MPNSTs和15例神经鞘瘤的临床和影像学特征。结果MPNSTs最大直径> 5cm者占88%，神经鞘瘤占15%，而脊髓哑铃型MPNSTs最大直径> 5cm者占15%。14%）。不规则分叶状边缘常发生在MPNST（75%），而在神经鞘瘤中不常见（21%）.在63%的MPNST中观察到边界难以区分，但只有7%的神经鞘瘤。溶骨性骨质破坏仅见于MPNSTs（50%的MPNSTs vs.0%的神经鞘瘤）。最大直径> 5cm，形态不规则分叶状，边界与周围组织难以区分，溶骨性骨质破坏是脊髓哑铃型MPNST的影像学特征。
Purpose To investigate the clinical outcomes and imaging features of malignant peripheral nerve sheath tumors (MPNSTs) presenting as spinal dumbbell tumors.Methods We retrospectively reviewed the clinical outcomes and imaging features of consecutive cases of spinal dumbbell MPNSTs (n = 8) and schwannomas (n = 15).Results A maximal diameter > 5 cm was more frequently seen in MPNSTs (88 %) than in schwannomas (14 %). Irregularly lobulated margins occurred frequently in MPNSTs (75 %), but not in schwannomas (21 %). Indistinguishable boundaries were observed in 63 % of MPNSTs, but only 7 % of schwannomas. Osteolytic bone destruction was found exclusively in MPNSTs (50 % of MPNSTs vs. 0 % of schwannomas).Conclusions There is little clinical information relating to spinal dumbbell MPNSTs. We propose that the following imaging features are suggestive of spinal dumbbell MPNSTs: maximal diameter > 5 cm, irregularly lobulated shape, boundary indistinguishable from surrounding tissues, and osteolytic bone destruction.