Delta 9-tetrahydrocannabinol enhances presynaptic dopamine efflux in medial prefrontal cortex.
Delta 9-tetrahydrocannabinol enhances presynaptic dopamine efflux in medial prefrontal cortex.
复制标题
Delta 9-四氢大麻酚增强内侧前额皮质的突触前多巴胺流出。
DOI：
10.1016/0014-2999(90)94136-l
复制
发表时间：
1990
影响因子：
5
通讯作者：
Gardner,EL
中科院分区：
文献类型：
--
作者：
Chen,J;Paredes,W;Lowinson,JH;Gardner,EL
在清醒行为大鼠脑内微透析法观察到，急性给予Δ9-四氢大麻酚(9-Δ，9-THC)可增加大鼠前额叶内侧皮质的突触前多巴胺(DA)外流。这些数据与以下观点是一致的：(1)大麻的愉悦效应和滥用潜力可能与突触前DA机制的增强有关，(2)内侧前额叶皮质可能是滥用药物的重要作用部位，特别是对Δ-9-THc。
Acute administration of 1.0–2.0 mg/kgΔ9-tetrahydrocannabinoIΔ9-THC) increased presynaptic dopamine (DA) efflux in the medial prefrontal cortex of rats, as measured by intracerebral microdialysis in awake, behaving rats. These data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic DA mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and forΔ9-THC in particular.