A randomized comparative study of sulbactam plus ampicillin vs. metronidazole plus cefotaxime in the management of acute appendicitis in children.
A randomized comparative study of sulbactam plus ampicillin vs. metronidazole plus cefotaxime in the management of acute appendicitis in children.
复制标题
舒巴坦联合氨苄青霉素与甲硝唑联合头孢噻肟治疗儿童急性阑尾炎的随机比较研究。
DOI：
10.1093/clinids/8.supplement_5.s634
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
R. Slack
中科院分区：
文献类型：
--
作者：
M. C. Foster;L. Kapila;D. Morris;R. Slack
舒巴坦是一种β -内酰胺酶抑制剂，当与氨苄青霉素联合使用时，使后者具有广谱活性，使其适合用作急性阑尾炎的预防剂。在一项单盲随机试验中，比较了舒巴坦加氨苄西林与甲硝唑加头孢噻肟的疗效。行阑尾切除术的35例患儿静脉注射舒巴坦和氨苄西林，38例患儿静脉注射甲硝唑和头孢噻肟。除非阑尾被认为是坏疽或穿孔，否则给予单次剂量，在这种情况下，药物给予72小时。舒巴坦、氨苄西林组创面感染3例，甲硝唑、头孢噻肟组创面感染5例。舒巴坦联合氨苄西林耐受性良好，在预防阑尾切除术后脓毒症方面至少与甲硝唑和头孢噻肟一样有效。
Sulbactam is a beta-lactamase inhibitor that, when combined with ampicillin, gives the latter antibiotic a broad spectrum of activity, making it suitable for use as a prophylactic agent in acute appendicitis. In a single-blind, randomized trial, the efficacy of sulbactam plus ampicillin was compared with that of metronidazole plus cefotaxime. Thirty-five children undergoing appendectomy received intravenous sulbactam and ampicillin, while 38 children received metronidazole and cefotaxime. Single doses were given unless the appendix was considered gangrenous or perforated, in which case the drugs were administered for 72 hr. There were three wound infections in the group given sulbactam and ampicillin and five in the group given metronidazole and cefotaxime. The combination of sulbactam and ampicillin was well tolerated and appeared to be at least as effective as that of metronidazole and cefotaxime in the prevention of sepsis following appendectomy.