Platelets in defense against bacterial pathogens.
Platelets in defense against bacterial pathogens.
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DOI：
10.1007/s00018-009-0210-4
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发表时间：
2010-02
影响因子：
8
通讯作者：
Yeaman, Michael R.
中科院分区：
文献类型：
--
作者：
Yeaman, Michael R.
血小板通过广泛的细胞和分子机制与细菌病原体相互作用。这种相互作用的后果可能会严重影响感染和免疫之间的平衡。一方面，最近的数据表明，某些细菌可能能够利用这些相互作用来获得毒力优势。事实上，某些细菌病原体似乎已经进化出特定的方式来颠覆激活的血小板。因此，可以想象，一些细菌病原体利用了血小板反应。另一方面，现在已知血小板具有明确的宿主防御效应细胞的结构和功能。最近的发现强调了实现这些功能的关键功能，包括检测细菌感染标志信号的Toll样受体的表达，一系列杀菌肽，以及其他宿主防御分子和功能。这些概念与细菌感染风险和严重性的增加是一致的，因为它们与临床上血小板数量和质量的异常相关。在这些方面，结合血小板免疫生物学的进展，探讨了血小板在宿主防御细菌病原体中的分子和细胞作用。
Platelets interact with bacterial pathogens through a wide array of cellular and molecular mechanisms. The consequences of this interaction may significantly influence the balance between infection and immunity. On the one hand, recent data indicate that certain bacteria may be capable of exploiting these interactions to gain a virulence advantage. Indeed, certain bacterial pathogens appear to have evolved specific ways in which to subvert activated platelets. Hence, it is conceivable that some bacterial pathogens exploit platelet responses. On the other hand, platelets are now known to possess unambiguous structures and functions of host defense effector cells. Recent discoveries emphasize critical features enabling such functions, including expression of toll-like receptors that detect hallmark signals of bacterial infection, an array of microbicidal peptides, as well as other host defense molecules and functions. These concepts are consistent with increased risk and severity of bacterial infection as correlates of clinical abnormalities in platelet quantity and quality. In these respects, the molecular and cellular roles of platelets in host defense against bacterial pathogens are explored with attention on advances in platelet immunobiology.
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影响因子：
15.9
作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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作者：
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