Effects of age on muscle as measured by electrical impedance myography
Effects of age on muscle as measured by electrical impedance myography
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DOI：
10.1088/0967-3334/27/10/002
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发表时间：
2006-10-01
影响因子：
3.2
通讯作者：
Rutkove, Seward B.
中科院分区：
文献类型：
--
作者：
Aaron, Ronald;Esper, Gregory J.;Rutkove, Seward B.
电阻抗肌电图（EIM）是一种无痛和非侵入性的技术，用于评估肌肉，我们在这里适用于正常老化的影响。本文介绍了一个横断面分析的EIM数据从股四头肌和胫骨前肌的100名健康受试者（44名男性，56名女性，年龄18 - 90岁）。主要的EIM参数，空间平均相位θ（平均值），显示出随着年龄的增加，大致二次减少，下降更陡峭超过60岁。男性的相关性更强（四头肌：男性r（2）= 0.68，女性r（2）= 0.52;胫骨前肌：男性r（2）= 0.74，女性r（2）= 0.38; p < 0.001）。此外，要求4名受试者（年龄大于75岁）在初次评估后数年返回进行重复检测。这些纵向结果定性地证实了横截面数据，尽管在高年龄时θ（avg）有更大的降低。这项研究的结果支持潜在的使用EIM作为一个简单的和努力独立的测试肌肉健康的老年人。
Electrical impedance myography ( EIM) is a painless and non-invasive technique for the assessment of muscle which we apply here to the effects of normal aging. The paper presents a cross-sectional analysis of EIM data from the quadriceps and tibialis anterior of 100 healthy subjects ( 44 men, 56 women, ages 18 - 90 years). The principal EIM parameter, the spatially averaged phase theta(avg), shows a roughly quadratic reduction with increasing age, declining more steeply beyond 60 years. The correlation was stronger in men ( quadriceps: r(2) = 0.68 for men, 0.52 for women; tibialis anterior: r(2) = 0.74 for men, 0.38 for women; p < 0.001 throughout). Additionally, four subjects ( age greater than 75 years) were asked to return for repeat testing several years after their initial assessment. These longitudinal results qualitatively confirm the cross-sectional data, though with greater reductions in theta(avg) at high age. The findings of this study support the potential use of EIM as a simple and effort-independent test of muscle health in the elderly.