ORIGINAL CONTRIBUTION Case-control Study of Bowel Habits and Colorectal Adenoma and Cancer

ORIGINAL CONTRIBUTION Case-control Study of Bowel Habits and Colorectal Adenoma and Cancer
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原创贡献排便习惯与结直肠腺瘤和癌症的病例对照研究

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发表时间：
2007
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通讯作者：
Seibi Kobayashi
Seibi Kobayashi
中科院分区：
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作者：
Ikuko;Kato;Suketami;Tominaga;A. Matsuura;Y. Yoshii;Masato;Shirai;Seibi Kobayashi

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在一项病例对照研究中研究了排便习惯与结直肠肿瘤之间的关系，该研究包括520例结直肠腺瘤，217例结直肠癌，638例无大肠内镜检查结果的医院对照和577例人群对照。与人群对照组相比，结直肠腺瘤和癌各部位软便的相对危险度（RR）增加，结直肠腺瘤和癌硬便的相对危险度（RR）增加。然而，在医院对照组中未观察到这些相关性。直肠和远端结肠腺瘤和直肠癌的RR与任一对照组相比，随着排便次数的增加而逐渐增加。与医院对照组相比，经其他混杂因素调整后，远端结肠腺瘤、直肠腺瘤和直肠癌患者每天排便两次或两次以上的RR分别为2.11（95%置信区间（CI）：1.24-3.60）、3.52（95% CI：1.56-7.93）和7.72（95% CI：3.18-18.76）。所有这些关联都不太可能用疾病的影响来解释。这些结果表明，表明腹泻和潜在炎症的排便习惯可能会增加远端结肠和直肠肿瘤的风险。流行病学杂志，1993; 3：1-5.
The association between bowel habits and colorectal neoplasms was studied in a casecontrol study involving 520 cases with colorectal adenoma, 217 cases with colorectal cancer, 638 hospital controls without no endoscopical findings in the large intestine and 577 population controls. Compared with population controls, the relative risk (RR) for soft stools were increased for every site of colorectal adenoma and cancer and that for hard stools was increased for colon adenoma and cancer. However, these associations were not observed with hospital controls. The RRs for rectal and distal colon adenomas and rectal cancer, compared with either control group, progressively increased with increasing the number of bowel movements. The RR for two or more bowel movements per day, adjusted for other confounding factors, was 2.11 (95% confidence interval (CI): 1.24-3.60) for distal colon adenoma, 3.52 (95% CI : 1.56-7.93) for rectal adenoma and 7.72 (95% Cl : 3.18-18.76) for rectal cancer, compared with hospital controls. All of the associations are not likely to be explained by effects of disease. These results suggest that bowel habits indicating diarrhea and underlying inflammation may increase the risk of neoplasms in the distal colon and rectum. J Epidemiol, 1993; 3 : 1-5.