Relationship Between Radiomics and Risk of Lymph Node Metastasis in Pancreatic Ductal Adenocarcinoma
Relationship Between Radiomics and Risk of Lymph Node Metastasis in Pancreatic Ductal Adenocarcinoma
复制标题
放射组学与胰腺导管腺癌淋巴结转移风险之间的关系。
DOI：
10.1097/mpa.0000000000001404
复制
发表时间：
2019-10-01
期刊：
影响因子：
2.9
通讯作者：
Lu, Jianping
中科院分区：
文献类型：
--
作者：
Bian, Yun;Guo, Shiwei;Lu, Jianping
目的探讨胰腺导管腺癌(PDAC)动脉放射组学评分(RAD-Score)与淋巴结转移的关系。方法对2016年12月至2017年8月经手术病理证实的225例PDAC患者在手术后1个月内行多层螺旋CT扫描。对每个患者，提取1029个动脉期放射组学特征，并使用最小绝对收缩和选择算子Logistic回归算法对特征进行约简。用多因素Logistic回归模型分析动脉RAD积分与LN转移的关系。结果淋巴结阴性患者107例(47.56%)，LN阳性患者118例(52.44%)。RAD评分包括12个选定的动脉期特征，与LN状态显著相关(P<；0.05)。单因素分析显示，动脉RAD积分和T分期与LN转移风险独立正相关(P<；0.05)。多变量分析显示动脉RAD评分与LN转移显著相关(P<；0.0001)。较高的动脉RAD积分与LN转移相关(P
Objective The objective of this study was to explore the exact relationship between the arterial radiomics score (rad-score) and lymph node (LN) metastasis in pancreatic ductal adenocarcinoma (PDAC). Methods A total of 225 patients with pathologically confirmed PDAC who underwent multislice computed tomography within 1 month of resection from December 2016 to August 2017 were retrospectively studied. For each patient, 1029 radiomics features of arterial phase were extracted, which were reduced using the least absolute shrinkage and selection operator logistic regression algorithm. Multivariate logistic regression models were used to analyze the association between the arterial rad-score and LN metastasis. Results Lymph node-negative and LN-positive patients accounted for 107 (47.56%) and 118 (52.44%) of the cohort, respectively. The rad-score, which consisted of 12 selected features of the arterial phase, was significantly associated with LN status (P < 0.05). Univariate analysis revealed that the arterial rad-score and T stage were independently and positively associated with risk of LN metastasis (P < 0.05). Multivariate analyses revealed a significant association between the arterial rad-score and the LN metastasis (P < 0.0001). Higher arterial rad-score was associated with LN metastasis (P for trend