The New Unified International Diabetes Federation/American Heart Association/National Heart, Lung, and Blood Institute Metabolic Syndrome Definition: Does It Correlate Better with C-reactive Protein in Chinese Patients Diagnosed with Type 2 Diabetes?
The New Unified International Diabetes Federation/American Heart Association/National Heart, Lung, and Blood Institute Metabolic Syndrome Definition: Does It Correlate Better with C-reactive Protein in Chinese Patients Diagnosed with Type 2 Diabetes?
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DOI：
10.1177/147323001003800605
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发表时间：
2010-11-01
影响因子：
1.6
通讯作者：
Hu, R.
中科院分区：
文献类型：
--
作者：
Lu, B.;Zhang, S.;Hu, R.
本研究在506名中国2型糖尿病患者中评估了高敏感性c反应蛋白（hsCRP）与代谢综合征（由国际糖尿病联合会（IDF）、美国心脏协会（AHA）和国家心肺血液研究所（NHLBI）提出的定义与较旧的IDF定义）之间的关系。采用多元线性回归模型对人体测量和生化参数进行比较和分析。在两种定义下，代谢综合征患者的血清hsCRP均高于无代谢综合征患者，并且随着代谢综合征成分数量的增加而增加（在调整了年龄、性别和吸烟因素后）。根据IDF/AHA/NHLBI而非IDE定义的代谢综合征患者的hsCRP水平明显高于不符合任何一种定义的患者，并且与符合两种定义的患者的hsCRP水平相似。根据IDF定义，调整年龄、性别和吸烟后，血清hsCRP水平与代谢综合征显著相关。根据IDF/AHA/NHLBI定义加入代谢综合征状态显著增加多元线性回归模型的拟合。新的IDF/AHA/NHLBI对代谢综合征的定义可能比IDF定义与血清hsCRP有更强的关系。
This study evaluated the association between high-sensitivity C-reactive protein (hsCRP) and metabolic syndrome, defined by the definition proposed by the International Diabetes Federation (IDF), American Heart Association (AHA) and National Heart, Lung, and Blood Institute (NHLBI) versus the older IDF definition, in 506 Chinese patients with type 2 diabetes. Anthropometric and biochemical parameters were compared and analysed using multivariate linear regression models. Serum hsCRP was higher in patients with metabolic syndrome compared with those without metabolic syndrome for both definitions and increased as the number of components of metabolic syndrome increased (after adjusting for age, gender and smoking). Patients with metabolic syndrome according to the IDF/AHA/NHLBI but not the IDE definition had significantly higher hsCRP levels than those not meeting either definition and similar hsCRP levels to those meeting both definitions. Serum hsCRP levels were significantly associated with metabolic syndrome according to the IDF definition after adjusting for age, gender and smoking. Adding metabolic syndrome status according to the IDF/AHA/NHLBI definition significantly increased the fit of the multivariate linear regression model. The new IDF/AHA/NHLBI definition of metabolic syndrome may have a stronger relationship with serum hsCRP than the IDF definition.