Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma
Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma
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DOI：
10.3892/or_00000332
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发表时间：
2009-04-01
期刊：
影响因子：
4.2
通讯作者：
Li, En-Min
中科院分区：
文献类型：
--
作者：
Huang, Xin;Xiao, Da-Wei;Li, En-Min
转化生长因子β (tgf - β)信号通路在生长发育中起着重要作用，在肿瘤的发生发展中起着至关重要的作用。Syndecan-2 （SDC2）和CYR61 （CYR61）是该通路中的重要基因，SDC2是tgf - β信号传导的重要上游调节因子。然而，SDC2和CYR61在食管鳞状细胞癌（ESCC）发展中的作用尚不清楚。在本研究中，我们探讨了SDC2和CYR61 mRNA表达水平与ESCC患者疾病预后的关系。采用实时荧光定量RT-PCR检测77例组织标本中SDC2和CYR61 mRNA的表达。实时定量RT-PCR结果显示，SDC2和CYR61 mRNA在ESCC组织中表达异常(P
The transforming growth factor beta (TGF-beta) signaling pathway plays an important role in growth and development, and is critically involved in the genesis and development of tumors. Syndecan-2 (SDC2) and Cysteine-rich 61 (CYR61) are important genes in this pathway and SDC2 is known to be a significant upstream regulator of TGF-beta signaling. However, the roles of SDC2 and CYR61 in the development of esophageal squamous cell carcinoma (ESCC) remain unclear. In the present study, we investigated the relationship between SDC2 and CYR61 mRNA expression levels and disease prognosis in patients with ESCC. The mRNA expression of SDC2 and CYR61 was detected by quantitative real-time RT-PCR in 77 tissue specimens. Quantitative realtime RT-PCR showed that SDC2 and CYR61 mRNA expression levels were aberrant in ESCC tissue (P