Nanotechnology for CNS delivery of bio-therapeutic agents.
Nanotechnology for CNS delivery of bio-therapeutic agents.
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DOI：
10.1007/s13346-013-0133-3
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发表时间：
2013-08-01
影响因子：
5.4
通讯作者：
Amiji, Mansoor
中科院分区：
文献类型：
--
作者：
Shah, Lipa;Yadav, Sunita;Amiji, Mansoor
关键词：
The current therapeutic strategies are not efficient in treating disorders related to the central nervous system (CNS) and have only shown partial alleviation of symptoms, as opposed to, disease modifying effects. With change in population demographics, the incidence of CNS disorders, especially neurodegenerative diseases, is expected to rise dramatically. Current treatment regimens are associated with severe side-effects, especially given that most of these are chronic therapies and involve elderly population. In this review, we highlight the challenges and opportunities in delivering newer and more effective bio-therapeutic agents for the treatment of CNS disorders. Bio-therapeutics like proteins, peptides, monoclonal antibodies, growth factors, and nucleic acids are thought to have a profound effect on halting the progression of neurodegenerative disorders and also provide a unique function of restoring damaged cells. We provide a review of the nano-sized formulation-based drug delivery systems and alternate modes of delivery, like the intranasal route, to carry bio-therapeutics effectively to the brain.
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影响因子：
4.5
作者：
Alcalá-Barraza SR;Lee MS;Hanson LR;McDonald AA;Frey WH 2nd;McLoon LK
通讯作者：
McLoon LK
影响因子：
3.8
作者：
Dhuria, Shyeilla V.;Hanson, Leah R.;Frey, William H., II
通讯作者：
Frey, William H., II
影响因子：
4.9
作者：
Ganta, Srinivas;Amiji, Mansoor
通讯作者：
Amiji, Mansoor
影响因子：
6.2
作者：
Fortin, David;Gendron, Cathy;Garant, Marie-Pierre
通讯作者：
Garant, Marie-Pierre
影响因子：
2.6
作者：
Danielyan, Lusine;Schaefer, Richard;Frey, William H., II
通讯作者：
Frey, William H., II