Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?
Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?
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DOI：
10.1136/ard.2009.120329
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发表时间：
2010-06-01
影响因子：
27.4
通讯作者：
Shoenfeld, Y.
中科院分区：
文献类型：
--
作者：
Amital, H.;Szekanecz, Z.;Shoenfeld, Y.
背景：在几种自身免疫性疾病中已报道有低血清维生素D浓度的情况。
目的：评估低血清维生素D浓度是否与系统性红斑狼疮（SLE）患者的疾病活动度相关。
方法：汇集了来自几个欧洲和以色列队列的378名患者，并通过两种不同的方法测量他们的疾病活动度：278名患者有SLE疾病活动指数 - 2000（SLEDAI - 2K）评分，100名患者有欧洲狼疮活动度测量共识（ECLAM）评分。为了结合这两个系统，将评分转换为标准化值（z分数），从而能够对这两个变量（SLEDAI - 2K和ECLAM）进行单变量汇总统计。使用商业试剂盒LIAISON 25 - OH维生素D检测（310900 - Diasorin）测量378名SLE患者的25 - OH维生素D血清浓度。
结果：通过SLEDAI - 2K和ECLAM量表测量，维生素D的血清浓度与疾病活动度评分的标准化值（z分数）之间显示出显著的负相关（皮尔逊相关系数r = -0.12，p = 0.018）。
结论：在来自以色列和欧洲的一组SLE患者中，发现维生素D血清浓度与疾病活动度呈负相关。
Background Low serum vitamin D concentrations have been reported in several autoimmune disorders. Objective To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE).Methods 378 patients from several European and Israeli cohorts were pooled and their disease activity was measured by two different methods: 278 patients had SLE disease activity-2000 (SLEDAI-2K) scores and 100 patients had European Consensus Lupus Activity Measurement (ECLAM) scores. In order to combine the two systems the scores were converted into standardised values (z-scores), enabling univariate summary statistics for the two variables (SLEDAI-2K and ECLAM). The commercial kit, LIAISON 25-OH vitamin D assay (310900-Diasorin) was used to measure serum concentration of 25-OH vitamin D in 378 patients with SLE.Results A significant negative correlation was demonstrated between the serum concentration of vitamin D and the standardised values (z-scores) of disease activity scores as measured by the SLEDAI-2K and ECLAM scales (Pearson's correlation coefficient r = -0.12, p = 0.018).Conclusions In a cohort of patients with SLE originating from Israel and Europe vitamin D serum concentrations were found to be inversely related to disease activity.