Potential and problems in ultrasound-responsive drug delivery systems.
Potential and problems in ultrasound-responsive drug delivery systems.
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超声响应药物输送系统的潜力和问题。
DOI：
10.2147/ijn.s43589
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发表时间：
2013
影响因子：
8
通讯作者：
Ge SP
中科院分区：
文献类型：
--
作者：
Zhao YZ;Du LN;Lu CT;Jin YG;Ge SP
超声是触发靶组织药物释放的重要局部刺激。超声响应药物递送系统（URDDS）已成为靶向治疗的重要研究热点。 URDDS包括许多不同的制剂，例如微泡、纳米泡、纳米滴、脂质体、乳液和胶束。 URDDS可装载的药物包括小分子、生物大分子和无机物。临床应用领域包括抗癌治疗、缺血性心肌治疗、诱导免疫反应、软骨组织工程、透皮给药、亨廷顿病治疗、溶栓和血脑屏障破坏。本综述重点介绍了 URDDS 的最新进展，讨论了它们的配方、临床应用和问题，以及对其未来潜在用途的展望。
Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington’s disease, thrombolysis, and disruption of the blood–brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.