Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training.
Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training.
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DOI：
10.3233/jad-190977
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Lu H
中科院分区：
文献类型：
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作者：
Thomas BP;Tarumi T;Sheng M;Tseng B;Womack KB;Cullum CM;Rypma B;Zhang R;Lu H
有氧运动（AE）在预防阿尔茨海默病（AD）中的作用近年来受到越来越多的关注。有证据表明，它可以改善老年人的神经认知功能。然而，这些改进的机制并不完全清楚。在这项前瞻性临床试验中，30名遗忘型轻度认知障碍参与者被纳入两组，并接受了12个月的干预。一组（n = 15）进行AE训练（8 M/7 F，年龄= 66.4岁），而另一组（n = 15）进行拉伸训练（8 M/7 F，年龄= 66.1岁）作为对照干预。两组均进行25-30分钟的训练，每周3次。随着时间的推移，频率和持续时间逐渐增加。为期10个月的AE训练改善了心肺功能（p = 0.04）和记忆功能（p = 0.004）。在训练前和训练后使用伪连续动脉自旋标记MRI测量脑血流量（CBF）。相对于拉伸组，AE组显示前扣带皮层中的CBF的训练相关增加（p = 0.016）。此外，在个体之间，记忆改善的程度与前扣带皮层和相邻前额叶皮层的CBF增加相关（体素方面p < 0.05）。相反，与牵拉组相比，AE导致后扣带回皮质CBF降低（p = 0.01）。这些结果表明，AE在AD中的有益作用可能是通过脑内AD敏感区域的血流和神经活动的重新分布来介导的。
Aerobic exercise (AE) has recently received increasing attention in the prevention of Alzheimer’s disease (AD). There is some evidence that it can improve neurocognitive function in elderly individuals. However, the mechanism of these improvements is not completely understood. In this prospective clinical trial, thirty amnestic mild cognitive impairment participants were enrolled into two groups and underwent 12 months of intervention. One group (n = 15) performed AE training (8M/7F, age = 66.4 years), whereas the other (n = 15) performed stretch training (8M/7F, age = 66.1 years) as a control intervention. Both groups performed 25–30 minutes training, 3 times per week. Frequency and duration were gradually increased over time. Twelve-month AE training improved cardiorespiratory fitness (p = 0.04) and memory function (p = 0.004). Cerebral blood flow (CBF) was measured at pre- and post-training using pseudo-continuous-arterial-spin-labeling MRI. Relative to the stretch group, the AE group displayed a training-related increase in CBF in the anterior cingulate cortex (p = 0.016). Furthermore, across individuals, the extent of memory improvement was associated with CBF increases in anterior cingulate cortex and adjacent prefrontal cortex (voxel-wise p < 0.05). In contrast, AE resulted in a decrease in CBF of the posterior cingulate cortex, when compared to the stretch group (p = 0.01). These results suggest that salutary effects of AE in AD may be mediated by redistribution of blood flow and neural activity in AD-sensitive regions of brain.