The JMJD family of histone demethylase and their intimate links to cardiovascular disease
The JMJD family of histone demethylase and their intimate links to cardiovascular disease
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DOI：
10.1016/j.cellsig.2024.111046
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发表时间：
2024-01-20
影响因子：
4.8
通讯作者：
Wang，Ming
中科院分区：
文献类型：
--
作者：
Xie，Jiarun;Lin，Haoyu;Wang，Ming
心血管疾病的发病率和死亡率均居世界首位。它与各种高危因素有关，没有单一的原因。DNA甲基化或组蛋白修饰等表观遗传修饰积极参与心血管疾病的发生和发展。组蛋白赖氨酸甲基化是组蛋白翻译后修饰的一种。人类Jumonji C结构域（JMJD）蛋白家族由30多个成员组成。JMJD蛋白参与许多关键的核过程，并在基因表达、DNA损伤和修复以及DNA复制的特异性调节中发挥关键作用。更重要的是，越来越多的证据表明，JM JD蛋白在心血管疾病中异常表达，这可能是这些疾病发生发展的潜在机制。在这里，我们讨论了JM JD蛋白在各种常见心血管疾病中的关键作用。这包括组蛋白赖氨酸脱甲基酶，这已经深入研究，和较少研究的JMJD成员。此外，我们还重点介绍了JM JD各成员引起的表观遗传学变化，总结了近年来的研究进展，并评价了其与心血管疾病的关系和治疗潜力。
The incidence rate and mortality rate of cardiovascular disease rank first in the world. It is associated with various high-risk factors, and there is no single cause. Epigenetic modifications, such as DNA methylation or histone modification, actively participate in the initiation and development of cardiovascular diseases. Histone lysine methylation is a type of histone post-translational modification. The human Jumonji C domain (JMJD) protein family consists of more than 30 members. JMJD proteins participate in many key nuclear processes and play a key role in the specific regulation of gene expression, DNA damage and repair, and DNA replication. Importantly, increasing evidence shows that JMJD proteins are abnormally expressed in cardiovascular diseases, which may be a potential mechanism for the occurrence and development of these diseases. Here, we discuss the key roles of JMJD proteins in various common cardiovascular diseases. This includes histone lysine demethylase, which has been studied in depth, and less-studied JMJD members. Furthermore, we focus on the epigenetic changes induced by each JMJD member, summarize recent research progress, and evaluate their relationship with cardiovascular diseases and therapeutic potential.