A chimeric prokaryotic ancestry of mitochondria and primitive eukaryotes
A chimeric prokaryotic ancestry of mitochondria and primitive eukaryotes
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DOI：
10.1073/pnas.96.16.9190
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发表时间：
1999-08-03
影响因子：
11.1
通讯作者：
Spormann, AM
中科院分区：
文献类型：
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作者：
Karlin, S;Brocchieri, L;Spormann, AM
我们提供的数据和分析支持这一假设，即动物线粒体(Mt)和许多原始线粒体(a-mt)真核生物的祖先是由类梭状真细菌和类硫杆菌类古细菌组成的融合微生物。分析基于几个观察结果：(1)梭状芽孢杆菌和硫杆菌的基因组特征(二核苷酸相对丰度值)是相容的(充分相似)，并且它们与动物mt序列的基因组特征比所有其他可用原核生物的相似性要大得多。稳定的融合可能需要基因组签名中的相容，这是由质粒和宿主的相容所表明的。(2)聚变生物体的能量代谢的扩大对巩固这种聚变具有很强的选择性。(Iii)梭状芽胞杆菌内孢子形成的分子装置是真核细胞细胞核和细胞质发育的原料。
We provide data and analysis to support the hypothesis that the ancestor of animal mitochondria (Mt) and many primitive amitochondrial (a-Mt) eukaryotes was a fusion microbe composed of a Clostridium-like eubacterium and a Sulfolobus-like archaebacterium. The analysis is based on several observations: (i) The genome signatures (dinucleotide relative abundance values) of Clostridium and Sulfolobus are compatible (sufficiently similar) and each has significantly more similarity in genome signatures with animal Mt sequences than do all other available prokaryotes. That stable fusions may require compatibility in genome signatures is suggested by the compatibility of plasmids and hosts. (ii) The expanded energy metabolism of the fusion organism was strongly selective for cementing such a fusion. (iii) The molecular apparatus of endospore formation in Clostridium serves as raw material for the development of the nucleus and cytoplasm of the eukaryotic cell.