Developmental consequences of oxytocin
Developmental consequences of oxytocin
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DOI：
10.1016/s0031-9384(03)00151-3
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发表时间：
2003-08-01
影响因子：
2.9
通讯作者：
Carter, CS
中科院分区：
文献类型：
--
作者：
Carter, CS
本文研究了哺乳动物神经肽催产素 (OT) 对发育的影响。在成人中，OT 是下丘脑中最丰富的神经肽，具有整合功能，协调行为和生理过程。例如，OT 与分娩、哺乳、母亲行为和夫妻关系形成有关。此外，OT 能够调节对各种压力源的行为反应以及下丘脑-垂体-肾上腺 (HPA) 轴的反应性。新生儿可能会接触母体来源的激素，可能包括在围产期给予母亲以加速或延迟分娩的肽以及乳汁中的肽；然而，来自母亲的肽激素是否影响发育中的婴儿仍有待确定。在啮齿动物中，内源性 OT 在出生后早期首先合成，尽管此时其功能尚不清楚。新生草原田鼠的实验记录了 OT 和 OT 受体拮抗剂对社会行为产生直接和终生影响的能力，包括成年配对关系和亲子行为，以及 HPA 轴的反应性；大多数这些影响都是性别二态性的。总结了此类作用的可能机制，包括 Of 和加压素的长期变化。 (C) 2003 Elsevier Inc. 保留所有权利。
This paper examines the developmental effects of the mammalian neuropeptide, oxytocin (OT). In adults, OT is the most abundant neuropeptide in the hypothalamus and serves integrative functions, coordinating behavioral and physiological processes. For example, OT has been implicated in parturition, lactation, maternal behavior and pair bond formation. In addition, OT is capable of moderating behavioral responses to various stressors as well as the reactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Neonates may be exposed to hormones of maternal origin, possibly including peptides administered to the mother in the perinatal period to hasten or delay birth and in milk;, however, whether peptide hormones from the mother influence the developing infant remains to be determined. In rodents, endogenous OT is first synthesized during the early postnatal period, although its functions at this time are not well known. Experiments in neonatal prairie voles have documented the capacity of OT and OT receptor antagonists to have immediate and lifelong consequences for social behaviors, including adult pair bonding and parental behaviors, as well as the reactivity of the HPA axis; most of these effects are sexually dimorphic. Possible mechanisms for such effects, including long-lasting changes in Of and vasopressin, are summarized. (C) 2003 Elsevier Inc. All rights reserved.