Concentrations of α- and β-defensins in plasma of patients with inflammatory bowel disease
Concentrations of α- and β-defensins in plasma of patients with inflammatory bowel disease
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DOI：
10.1007/s00011-008-8120-8
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发表时间：
2009-01
影响因子：
6.7
通讯作者：
N. Yamaguchi;H. Isomoto;H. Mukae;H. Ishimoto;K. Ohnita;S. Shikuwa;Y. Mizuta;M. Nakazato;S. Kohno
中科院分区：
文献类型：
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作者：
N. Yamaguchi;H. Isomoto;H. Mukae;H. Ishimoto;K. Ohnita;S. Shikuwa;Y. Mizuta;M. Nakazato;S. Kohno
背景：内源性抗菌肽防御素的合成/释放异常与炎症性肠病的发病机制有关。材料与方法采用室内放射免疫分析方法，检测了55例炎症性肠病患者血浆中主要形式的α-防御素、人中性粒细胞多肽1-3和人β-防御素-2的浓度，其中溃疡性结肠炎29例，克罗恩病26例，对照组57例。CD患者血浆HNP1-3水平与克罗恩病活动指数、外周血白细胞计数、血清CRP值及肿瘤坏死因子-α水平呈显著正相关。结论CD患者循环α-防御素水平升高提示其在IBD发病中的生理病理作用。血浆HNP1-3浓度可能是CD活动性的一个指标，它们与C反应蛋白和肿瘤坏死因子-α的相关性可能与炎症过程有关。
BackgroundImpaired production/release of defensins, representative endogenous antimicrobial peptides, is associated with the pathogenesis of inflammatory bowel disease (IBD).Material and methodsEmploying in house radioimmunoassay, we examined concentrations of the major forms α-defensins, human neutrophil peptides (HNP) 1–3 and human β-defensin (HBD)-2 in plasma of 55 IBD patients consisting of 29 patients with ulcerative colitis (UC) and 26 with Crohn’s disease (CD) and 57 controls.ResultsThe circulating HNP 1–3, but not HBD-2, levels in IBD patients were significantly higher than those in controls. Plasma HNP 1–3 concentrations in CD patients significantly correlated with Crohn’s disease activity index, peripheral white blood cell counts, serum CRP values and TNF-α levels.ConclusionsElevation of circulating α-defensins levels is suggestive of their physiopathological roles in IBD. Plasma HNP 1–3 concentrations may be an indicator for CD activity and their association with CRP and TNF-α supports a possible association with the inflammatory process.