Nanoparticles Mimicking Viral Cell Recognition Strategies Are Superior Transporters into Mesangial Cells
Nanoparticles Mimicking Viral Cell Recognition Strategies Are Superior Transporters into Mesangial Cells
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DOI：
10.1002/advs.201903204
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发表时间：
2020-04-22
期刊：
影响因子：
15.1
通讯作者：
Goepferich, Achim
中科院分区：
文献类型：
--
作者：
Maslanka Figueroa, Sara;Fleischmann, Daniel;Goepferich, Achim
目的组织中药物可得性差是治疗失败的常见原因。虽然纳米技术已经开发出大量用于药物运输的纳米载体，但它们明确识别感兴趣的细胞的能力仍然有限。病毒是理想的纳米级载体，因为它们能够以高特异性定位其嵌入的核酸到宿主细胞。在这里，有报道称，与常规纳米颗粒相比，具有病毒样细胞识别能力的颗粒在体内识别系膜细胞（MCs）的能力更强。与缺乏一种或两种病毒特征的颗粒相比，模仿最初的病毒附着，然后逐步进行靶细胞识别过程，导致肾系膜的积聚和广泛的细胞摄取增加5至15倍。这些结果突出了病毒细胞鉴定过程与特异性及其在纳米材料靶向策略中的应用的相关性。更重要的是，这些发现为将药物输送到系膜铺平了道路，系膜是糖尿病肾病发展的关键组织，目前尚无有效的药物治疗方法。
Poor drug availability in the tissue of interest is a frequent cause of therapy failure. While nanotechnology has developed a plethora of nanocarriers for drug transport, their ability to unequivocally identify cells of interest remains moderate. Viruses are the ideal nanosized carriers as they are able to address their embedded nucleic acids with high specificity to their host cells. Here, it is reported that particles endowed with a virus-like ability to identify cells by three consecutive checks have a superior ability to recognize mesangial cells (MCs) in vivo compared to conventional nanoparticles. Mimicking the initial viral attachment followed by a stepwise target cell recognition process leads to a 5- to 15-fold higher accumulation in the kidney mesangium and extensive cell uptake compared to particles lacking one or both of the viral traits. These results highlight the relevance that the viral cell identification process has on specificity and its application on the targeting strategies of nanomaterials. More so, these findings pave the way for transporting drugs into the mesangium, a tissue that is pivotal in the development of diabetic nephropathy and for which currently no efficient pharmacotherapy exists.