The Effects of Aging on the Molecular and Cellular Composition of the Prostate Microenvironment
The Effects of Aging on the Molecular and Cellular Composition of the Prostate Microenvironment
复制标题
DOI：
10.1371/journal.pone.0012501
复制
发表时间：
2010-09-01
期刊：
影响因子：
3.7
通讯作者：
Nelson, Peter S.
中科院分区：
文献类型：
--
作者：
Bianchi-Frias, Daniella;Vakar-Lopez, Funda;Nelson, Peter S.
背景资料：年龄的增长与影响前列腺的常见疾病（包括良性前列腺增生（BPH）和前列腺癌）的发病率大幅增加有关。前列腺由功能性分泌上皮、基底上皮和由结构元件组成的支持基质以及包括平滑肌细胞、成纤维细胞和炎性细胞的一系列细胞类型组成。由于上皮和基质成分之间的相互作用对于正常器官形成是必不可少的，并且用于维持正常功能，基质内的不一致可能允许或促进疾病过程。在这项研究中，我们试图确定小鼠前列腺微环境中可能影响病理学的衰老相关改变。方法学/主要发现：我们定量了年轻（年龄4个月）和老年（年龄20-24个月）C57 BL/6小鼠显微解剖的腺体相邻基质中的转录水平，并确定了1259个基因表达的显著变化（p
Background: Advancing age is associated with substantial increases in the incidence rates of common diseases affecting the prostate gland including benign prostatic hyperplasia (BPH) and prostate carcinoma. The prostate is comprised of a functional secretory epithelium, a basal epithelium, and a supporting stroma comprised of structural elements, and a spectrum of cell types that includes smooth muscle cells, fibroblasts, and inflammatory cells. As reciprocal interactions between epithelium and stromal constituents are essential for normal organogenesis and serve to maintain normal functions, discordance within the stroma could permit or promote disease processes. In this study we sought to identify aging-associated alterations in the mouse prostate microenvironment that could influence pathology.Methodology/Principal Findings: We quantitated transcript levels in microdissected glandular-adjacent stroma from young (age 4 months) and old (age 20-24 months) C57BL/6 mice, and identified a significant change in the expression of 1259 genes (p