Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist
Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist
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DOI：
10.1161/01.str.0000027274.03779.f3
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发表时间：
2002-09-01
期刊：
影响因子：
8.3
通讯作者：
Saavedra, JM
中科院分区：
文献类型：
--
作者：
Ito, T;Yamakawa, H;Saavedra, JM
背景和目的：血管紧张素II AT(1)受体拮抗剂预处理对脑缺血具有保护作用。我们研究脑血流量（CBF）的调节和脑动脉形态学变化是否参与了这种保护机制。方法：我们用坎地沙坦（0.1或0.3 mg/kg /天）、尼卡地平（0.1 mg/kg /天）或卡托普利（30 mg/kg /天）等降压剂量皮下预处理成年自发性高血压大鼠3或28天渗透微型真空泵紧随其后的是永久的左大脑中动脉(MCA)闭塞远端纹状体外动脉增的起源我们测量CBF通过放射自显影法4碘[N甲基碳14]操作和安替比林3小时后梗塞和组织肿胀MCA术后24小时的形态学变化进行了研究后抗高血压treatmentResults-Twenty八天的坎地沙坦预处理减少梗死面积减少的CBF减少31%外周缺血区和脑血流所在的严重缺血性病变皮层体积
Background and Purpose-Pretreatment with angiotensin II AT(1) receptor antagonists protects against cerebral ischemia We studied whether modulation of cerebral blood flow (CBF) and morphometric changes in brain arteries participated in this protective mechanismMethods-We pretreated adult spontaneously hypertensive rats with equally antihypertensive doses of candesartan (0 1 or 0 3 mg/kg per day) nicardipine (0 1 mg/kg per day) or captopril (3 0 mg/kg per day) for 3 or 28 days via subcutaneous osmotic minipumps followed by permanent left middle cerebral artery (MCA) occlusion distal to the origin of the lenticulostriate arteries We measured CBF by autoradiography with 4 iodo [N methyl C-14]antipyrine 3 hours after operation and the areas of infarct and tissue swelling 24 hours after operation Morphometric changes in the MCA were studied after anti hypertensive treatmentResults-Twenty eight days of candesartan Pretreatment decreased the infarct area by 31% reduced the CBF decrease at the peripheral area of ischemia and the cortical volume of severe ischemic lesion where CBF was