Excitotoxic amino acids and neuropsychiatric disorders.
Excitotoxic amino acids and neuropsychiatric disorders.
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兴奋性毒性氨基酸和神经精神疾病。
DOI：
10.1146/annurev.pa.30.040190.000403
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发表时间：
1990
影响因子：
12.5
通讯作者：
Olney,JW
中科院分区：
文献类型：
--
作者：
Olney,JW
综述了目前兴奋性毒理学研究中的问题，并强调了N-甲基-天冬氨酸(NMDA)受体及其在神经退行性疾病中的可能作用。刺激毒素和神经退行性疾病被描述在以下类别中：食物兴奋毒素；代谢障碍；癫痫、低血糖和缺氧/缺血；中枢神经系统(CNS)损伤(如拳击性痴呆症)；阿尔茨海默病；以及WerNicke/Korsakoff综合征。讨论了NMDA受体和发育中的中枢神经系统与精神分裂症等神经精神障碍的关系。分析了NMDA受体在记忆损伤和衰老中的影响。(保留所有权利)
Reviews current issues in excitotoxicology research and emphasizes the N-methyl-{d}-aspartate (NMDA) receptor and its possible role in neurodegenerative diseases. Excitotoxins and neurodegenerative disorders are described within the categories of food excitotoxins; metabolic disorders; epilepsy, hypoglycemia and hypoxia/ischemia; and central nervous system (CNS) trauma (eg, dementia pugilistica); Alzheimer's disease; and Wernicke/Korsakoff syndrome. NMDA receptors and the developing CNS are discussed in relation to neuropsychiatric disorders such as schizophrenia. The influence of NMDA receptors in memory impairment and aging is analyzed.(PsycINFO Database Record (c) 2016 APA, all rights reserved)