Vitamin D: a new player in non-alcoholic fatty liver disease?
Vitamin D: a new player in non-alcoholic fatty liver disease?
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DOI：
10.3748/wjg.v21.i6.1718
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发表时间：
2015-02-14
影响因子：
4.3
通讯作者：
Spyrou, Elias
中科院分区：
文献类型：
--
作者：
Eliades, Myrto;Spyrou, Elias
维生素D通过其活性形式1a-25-二羟基维生素D [1,25(OH)(2)D]是一种辅助类固醇激素，在矿物质代谢中起关键作用。近年来，人们对维生素D的研究越来越感兴趣，并将其作用扩展到免疫调节、细胞分化和增殖以及炎症调节。随着我们对维生素D的许多功能的了解不断加深，维生素D缺乏症已成为世界上最普遍的微量营养素缺乏症之一。与此同时，非酒精性脂肪性肝病（NAFLD）已成为西方国家最常见的慢性肝病。NAFLD和维生素D缺乏经常共存，流行病学证据表明，这两种情况有几个共同的心脏代谢危险因素。在本文中，我们概述了NAFLD与维生素D缺乏之间的流行病学和病理生理学联系，以及在NAFLD中补充维生素D的临床应用的现有证据。
Vitamin D through its active form 1a-25-dihydroxyvtamin D [1,25(OH)(2)D] is a secosteroid hormone that plays a key role in mineral metabolism. Recent years have witnessed a significant scientific interest on vitamin D and expanded its actions to include immune modulation, cell differentiation and proliferation and inflammation regulation. As our understanding of the many functions of vitamin D has grown, the presence of vitamin D deficiency has become one of the most prevalent micronutrient deficiencies worldwide. Concomitantly, non-alcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in western countries. NAFLD and vitamin D deficiency often coexist and epidemiologic evidence has shown that both of these conditions share several cardiometabolic risk factors. In this article we provide an overview of the epidemiology and pathophysiology linking NAFLD and vitamin D deficiency, as well as the available evidence on the clinical utility of vitamin D supplementation in NAFLD.