Is the tail-strength measure more powerful in tests of genetic association?
Is the tail-strength measure more powerful in tests of genetic association?
复制标题
在遗传关联测试中尾部强度测量是否更有效？
DOI：
10.1016/j.ajhg.2009.01.015
复制
发表时间：
2009
影响因子：
9.8
通讯作者：
Yang,Bao-Zhu
中科院分区：
文献类型：
--
作者：
Han,Shizhong;Ma,Li;Li,Dawei;Yang,Bao-Zhu
To the Editor: It is well known that Hardy-Weinberg equilibrium (HWE) is an important property in population genetics. Deviation from HWE among cases can provide evidence for a valid association. 1–4 Thus, it would be advisable to incorporate information from the HWE test for the improvement of power in detecting associated variants in genetic association studies. In the July 2008 issue ofThe Journal, Wang et al. 5 described a test statistic, the tail-strength (TS) measure, 6 for evaluation of the global null hypothesis, that the SNP was not associated with disease, which is a function of two p values: one from a logistic-regression test in a genetic association study and one from a HWE test in cases. The authors further extended the mean-basedTSmeasure to a median-based measure (TSM) by measuring the deviation of each p value from its median value instead of its expected value. On the basis of simulation studies and real disease
